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KEGG    Network variation - Coagulation cascade
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ENTRYnt06514
NameCoagulation cascade
CategoryPathway view; Immune system
Pathwayhsa04610 Complement and coagulation cascades
DiseaseH00219 Hemophilia
H00223 Inherited thrombophilia
H01006 Hereditary angioedema
Display drug-target relation   disease type
   D8,D9,D10
 |		  
N01506    F12−Kallikrein→F12a
    FXII deficiency/HAE3 F12*
N01507      F11−F12a→F11a
    FXI deficiency   F11*
N01508        F9−F11a→F9a→(F9a+F8a)
     D3
 |
    HEMB/THPH8     F9*
     D2
 |		 D5,D6,D7,D4
 |		    
N01509        (F8+VWF)−(F10a,F2a)→F8a→(F9a+F8a)
    HEMA     F8*
    VWD     VWF*
 
   D5,D6,D7,D4
 |		    
N01503    F7−Protease→F7a→(F7a+F3)
    FVII deficiency/MI F7*
 
     D5,D6,D7
 |		 D5,D6,D7
 |
N01510    F10−((F9a+F8a),(F7a+F3..→F10a→(F10a+F5a)
    FX deficiency F10*
   D4
 |		   D5,D6,D7
 |
N01511    F5−F2a→F5a→(F10a+F5a)
    FV deficiency/THPH2/BDCHS F5*
       D5,D6,D7
 |		 D4
 |
N01512        F2−(F10a+F5a)→F2a
    FII deficiency/THPH1     F2*
         D4
 |		  
N01513          FG−F2a→Fibrin
    Afibrinogenemia/Amyloidosis       FGA*
    Afibrinogenemia       FGB*
    Afibrinogenemia       FGG*
         D4
 |		  
N01514          F13−F2a→F13a
    FXIIIA deficiency/MI       F13A1*
    FXIIIB deficiency       F13B*
         D4
 |
N01521          SERPIND1⊣F2a
    THPH10       SERPIND1*
 
N01518    PLG−(PLAU,PLAT)→Plasmin
    PLG deficiency/HAE4 PLG*
    QPD   PLAU*↗
N01524    PAI⊣(PLAU,PLAT)
    PAI-1 deficiency SERPINE1*
N01522      SERPINF2⊣Plasmin
    a2-PI deficiency   SERPINF2*
N01523      SERPINA1⊣(Plasmin,PLAU)
    A1AT deficiency/COPD   SERPINA1*
 
   D4
 |		      
N01515    PROC−(F2a+THBD+PROCR)→APC→(APC+PROS1)⊣(F5a,F8a)
    THPH3/4 PROC*
    THPH12   THBD*
    THPH5/6       PROS1*
 
     D8,D9,D10
 |
N01516    KLKB1−F12a→Kallikrein
    PKKD KLKB1*
     D8,D9,D10
 |		    
N01517      KNG1−Kallikrein→Bradykinin→BDKRB
    HAE6   KNG1*
 
   D8,D9,D10
 |
N01520    SERPING1⊣(F11a,F12a,Kallikr..
    C1NH deficiency/HAE1/2 SERPING1*
   D4,D5,D6,D7
 |
N01519    SERPINC1⊣(F2a,F9a,F10a,F11a..
    AT deficiency/THPH7 SERPINC1*
 
 D1
 |		    
N01831    ADAMTS13⊣VWF→(GP1BA+GP1BB+GP9+G..
    TTP ADAMTS13*
    BSS/PT-VWD     GP1BA*
    BSS     GP1BB*
    BSS     GP9*

Disease nameDisease category
FXII deficiency/HAE3H00941Factor XII deficiencyHematologic disease
H01006Hereditary angioedemaCardiovascular disease
FXI deficiencyH00938Factor XI deficiencyHematologic disease
HEMB/THPH8H00219HemophiliaHematologic disease
H00223Inherited thrombophiliaHematologic disease
HEMAH00219HemophiliaHematologic disease
VWDH02092von Willebrand diseaseHematologic disease
H00219HemophiliaHematologic disease
FVII deficiency/MIH02256Factor VII deficiencyHematologic disease
H01730Myocardial infarctionCardiovascular disease
FX deficiencyH02257Factor X deficiencyHematologic disease
FV deficiency/THPH2/BDCHSH00220Factor V deficiencyHematologic disease
H00223Inherited thrombophiliaHematologic disease
H01433Budd-Chiari syndromeDigestive system disease
FII deficiency/THPH1H01254Congenital prothrombin deficiencyHematologic disease
H00223Inherited thrombophiliaHematologic disease
Afibrinogenemia/AmyloidosisH00222AfibrinogenemiaHematologic disease
H00845Familial amyloidosisNervous system disease
AfibrinogenemiaH00222AfibrinogenemiaHematologic disease
FXIIIA deficiency/MIH00945Factor XIII deficiencyHematologic disease
H01730Myocardial infarctionCardiovascular disease
FXIIIB deficiencyH00945Factor XIII deficiencyHematologic disease
THPH10H00223Inherited thrombophiliaHematologic disease
PLG deficiency/HAE4H01206Plasminogen deficiencyHematologic disease
H01006Hereditary angioedemaCardiovascular disease
QPDH01235Bleeding disorder platelet-typeHematologic disease
PAI-1 deficiencyH01106Plasminogen activator inhibitor type 1 deficiencyHematologic disease
a2-PI deficiencyH00983Alpha-2-plasmin inhibitor (a2-PI) deficiencyHematologic disease
A1AT deficiency/COPDH01103Alpha-1-antitrypsin deficiencyInherited metabolic disorder
H01714Chronic obstructive pulmonary disease (COPD)Respiratory system disease
THPH3/4H00223Inherited thrombophiliaHematologic disease
THPH12H00223Inherited thrombophiliaHematologic disease
THPH5/6H00223Inherited thrombophiliaHematologic disease
PKKDH01078Fletcher factor deficiencyHematologic disease
HAE6H01006Hereditary angioedemaCardiovascular disease
C1NH deficiency/HAE1/2H00106Complement regulatory protein defectsPrimary immunodeficiency
H01006Hereditary angioedemaCardiovascular disease
AT deficiency/THPH7H01381Antithrombin III deficiencyHematologic disease
H00223Inherited thrombophiliaHematologic disease
TTPH00225Thrombotic thrombocytopenic purpuraCardiovascular disease
BSS/PT-VWDH01740MacrothrombocytopeniaHematologic disease
H02093Platelet-type von Willebrand diseaseHematologic disease
BSSH01740MacrothrombocytopeniaHematologic disease


Drug name
D1D12835Apadamtase alfa and cinaxadamtase alfa
D2D02235Desmopressin acetate (USP)
D3D12908Fidanacogene elaparvovec (USAN/INN)
D4D07082Dabigatran etexilate mesylate (USAN)
D5D03213Apixaban (JAN/USAN/INN)
D6D07086Rivaroxaban (JAN/USAN/INN)
D7D09546Edoxaban tosilate hydrate (JAN)
D8D03931Ecallantide (USAN/INN)
D9D11094Lanadelumab (USAN)
D10D11674Berotralstat hydrochloride (JAN/USAN)