Homo sapiens (human): 7450 Help Entry 7450              CDS       T01001                                  Symbol VWF, F8VWF, VWD Name (RefSeq) von Willebrand factor   KO K03900   von Willebrand factor Organism hsa  Homo sapiens (human) Pathway hsa04151   PI3K-Akt signaling pathway hsa04510   Focal adhesion hsa04512   ECM-receptor interaction hsa04610   Complement and coagulation cascades hsa04611   Platelet activation hsa04613   Neutrophil extracellular trap formation hsa05165   Human papillomavirus infection hsa05171   Coronavirus disease - COVID-19 Network nt06514  Coagulation cascade   Element N01509   Intrinsic pathway of coagulation cascade, F8 activation N01831   Regulation of VWF-GPIb-IX-V interaction, ADAMTS13 Disease H00219   Hemophilia H01740   Macrothrombocytopenia H02092   von Willebrand disease Drug target Caplacizumab:  D11160<JP/US> Coagulation factor VIII (DG00170):  D10758<JP> Egaptivon pegol:  D09892 Rondaptivon pegol:  D12863 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     7450 (VWF)   09133 Signaling molecules and interaction    04512 ECM-receptor interaction     7450 (VWF)  09150 Organismal Systems   09151 Immune system    04610 Complement and coagulation cascades     7450 (VWF)    04611 Platelet activation     7450 (VWF)    04613 Neutrophil extracellular trap formation     7450 (VWF)  09160 Human Diseases   09172 Infectious disease: viral    05171 Coronavirus disease - COVID-19     7450 (VWF)    05165 Human papillomavirus infection     7450 (VWF)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03110 Chaperones and folding catalysts [BR:hsa03110]     7450 (VWF)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hsa04147]     7450 (VWF) Chaperones and folding catalysts [BR:hsa03110]  Intramolecular chaperones   Others    7450 (VWF) Exosome [BR:hsa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    7450 (VWF) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  VWD VWA C8 VWA_N2 TIL VWC VWF Pacifastin_I MCR_beta_N Motif Other DBs NCBI-GeneID:  7450 NCBI-ProteinID:  NP_000543 OMIM:  613160 HGNC:  12726 Ensembl:  ENSG00000110799 UniProt:  P04275 Structure PDBPDBj LinkDB All DBs Position 12:complement(5948877..6124670) Genome browser AA seq 2813 aa AA seqDB search MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYL LAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYL ETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL TSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPL VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGME YRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPG TSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQD HSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDL RIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVS PLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQ CGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPED IFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADN LRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGE TVKIGCNTCVCQDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGS NPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGR YIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVD FGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPY LDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCE VAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVE DISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRI TLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVL SSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVA FVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGD ILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLP GDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTL SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT IDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILV TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM VTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCD RGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNK EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEV NVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRD GTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFY AICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHC DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQI CTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHC ERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVN STVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAV MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERME ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGEC CGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHK CLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMY SIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK NT seq 8442 nt NT seq  +upstreamnt  +downstreamnt atgattcctgccagatttgccggggtgctgcttgctctggccctcattttgccagggacc ctttgtgcagaaggaactcgcggcaggtcatccacggcccgatgcagccttttcggaagt gacttcgtcaacacctttgatgggagcatgtacagctttgcgggatactgcagttacctc ctggcagggggctgccagaaacgctccttctcgattattggggacttccagaatggcaag agagtgagcctctccgtgtatcttggggaattttttgacatccatttgtttgtcaatggt accgtgacacagggggaccaaagagtctccatgccctatgcctccaaagggctgtatcta gaaactgaggctgggtactacaagctgtccggtgaggcctatggctttgtggccaggatc gatggcagcggcaactttcaagtcctgctgtcagacagatacttcaacaagacctgcggg ctgtgtggcaactttaacatctttgctgaagatgactttatgacccaagaagggaccttg acctcggacccttatgactttgccaactcatgggctctgagcagtggagaacagtggtgt gaacgggcatctcctcccagcagctcatgcaacatctcctctggggaaatgcagaagggc ctgtgggagcagtgccagcttctgaagagcacctcggtgtttgcccgctgccaccctctg gtggaccccgagccttttgtggccctgtgtgagaagactttgtgtgagtgtgctgggggg ctggagtgcgcctgccctgccctcctggagtacgcccggacctgtgcccaggagggaatg gtgctgtacggctggaccgaccacagcgcgtgcagcccagtgtgccctgctggtatggag tataggcagtgtgtgtccccttgcgccaggacctgccagagcctgcacatcaatgaaatg tgtcaggagcgatgcgtggatggctgcagctgccctgagggacagctcctggatgaaggc ctctgcgtggagagcaccgagtgtccctgcgtgcattccggaaagcgctaccctcccggc acctccctctctcgagactgcaacacctgcatttgccgaaacagccagtggatctgcagc aatgaagaatgtccaggggagtgccttgtcacaggtcaatcacacttcaagagctttgac aacagatacttcaccttcagtgggatctgccagtacctgctggcccgggattgccaggac cactccttctccattgtcattgagactgtccagtgtgctgatgaccgcgacgctgtgtgc acccgctccgtcaccgtccggctgcctggcctgcacaacagccttgtgaaactgaagcat ggggcaggagttgccatggatggccaggacgtccagctccccctcctgaaaggtgacctc cgcatccagcatacagtgacggcctccgtgcgcctcagctacggggaggacctgcagatg gactgggatggccgcgggaggctgctggtgaagctgtcccccgtctatgccgggaagacc tgcggcctgtgtgggaattacaatggcaaccagggcgacgacttccttaccccctctggg ctggcggagccccgggtggaggacttcgggaacgcctggaagctgcacggggactgccag gacctgcagaagcagcacagcgatccctgcgccctcaacccgcgcatgaccaggttctcc gaggaggcgtgcgcggtcctgacgtcccccacattcgaggcctgccatcgtgccgtcagc ccgctgccctacctgcggaactgccgctacgacgtgtgctcctgctcggacggccgcgag tgcctgtgcggcgccctggccagctatgccgcggcctgcgcggggagaggcgtgcgcgtc gcgtggcgcgagccaggccgctgtgagctgaactgcccgaaaggccaggtgtacctgcag tgcgggaccccctgcaacctgacctgccgctctctctcttacccggatgaggaatgcaat gaggcctgcctggagggctgcttctgccccccagggctctacatggatgagaggggggac tgcgtgcccaaggcccagtgcccctgttactatgacggtgagatcttccagccagaagac atcttctcagaccatcacaccatgtgctactgtgaggatggcttcatgcactgtaccatg agtggagtccccggaagcttgctgcctgacgctgtcctcagcagtcccctgtctcatcgc agcaaaaggagcctatcctgtcggccccccatggtcaagctggtgtgtcccgctgacaac ctgcgggctgaagggctcgagtgtaccaaaacgtgccagaactatgacctggagtgcatg agcatgggctgtgtctctggctgcctctgccccccgggcatggtccggcatgagaacaga tgtgtggccctggaaaggtgtccctgcttccatcagggcaaggagtatgcccctggagaa acagtgaagattggctgcaacacttgtgtctgtcaggaccggaagtggaactgcacagac catgtgtgtgatgccacgtgctccacgatcggcatggcccactacctcaccttcgacggg ctcaaatacctgttccccggggagtgccagtacgttctggtgcaggattactgcggcagt aaccctgggacctttcggatcctagtggggaataagggatgcagccacccctcagtgaaa tgcaagaaacgggtcaccatcctggtggagggaggagagattgagctgtttgacggggag gtgaatgtgaagaggcccatgaaggatgagactcactttgaggtggtggagtctggccgg tacatcattctgctgctgggcaaagccctctccgtggtctgggaccgccacctgagcatc tccgtggtcctgaagcagacataccaggagaaagtgtgtggcctgtgtgggaattttgat ggcatccagaacaatgacctcaccagcagcaacctccaagtggaggaagaccctgtggac tttgggaactcctggaaagtgagctcgcagtgtgctgacaccagaaaagtgcctctggac tcatcccctgccacctgccataacaacatcatgaagcagacgatggtggattcctcctgt agaatccttaccagtgacgtcttccaggactgcaacaagctggtggaccccgagccatat ctggatgtctgcatttacgacacctgctcctgtgagtccattggggactgcgcctgcttc tgcgacaccattgctgcctatgcccacgtgtgtgcccagcatggcaaggtggtgacctgg aggacggccacattgtgcccccagagctgcgaggagaggaatctccgggagaacgggtat gagtgtgagtggcgctataacagctgtgcacctgcctgtcaagtcacgtgtcagcaccct gagccactggcctgccctgtgcagtgtgtggagggctgccatgcccactgccctccaggg aaaatcctggatgagcttttgcagacctgcgttgaccctgaagactgtccagtgtgtgag gtggctggccggcgttttgcctcaggaaagaaagtcaccttgaatcccagtgaccctgag cactgccagatttgccactgtgatgttgtcaacctcacctgtgaagcctgccaggagccg ggaggcctggtggtgcctcccacagatgccccggtgagccccaccactctgtatgtggag gacatctcggaaccgccgttgcacgatttctactgcagcaggctactggacctggtcttc ctgctggatggctcctccaggctgtccgaggctgagtttgaagtgctgaaggcctttgtg gtggacatgatggagcggctgcgcatctcccagaagtgggtccgcgtggccgtggtggag taccacgacggctcccacgcctacatcgggctcaaggaccggaagcgaccgtcagagctg cggcgcattgccagccaggtgaagtatgcgggcagccaggtggcctccaccagcgaggtc ttgaaatacacactgttccaaatcttcagcaagatcgaccgccctgaagcctcccgcatc accctgctcctgatggccagccaggagccccaacggatgtcccggaactttgtccgctac gtccagggcctgaagaagaagaaggtcattgtgatcccggtgggcattgggccccatgcc aacctcaagcagatccgcctcatcgagaagcaggcccctgagaacaaggccttcgtgctg agcagtgtggatgagctggagcagcaaagggacgagatcgttagctacctctgtgacctt gcccctgaagcccctcctcctactctgccccccgacatggcacaagtcactgtgggcccg gggctcttgggggtttcgaccctggggcccaagaggaactccatggttctggatgtggcg ttcgtcctggaaggatcggacaaaattggtgaagccgacttcaacaggagcaaggagttc atggaggaggtgattcagcggatggatgtgggccaggacagcatccacgtcacggtgctg cagtactcctacatggtgactgtggagtaccccttcagcgaggcacagtccaaaggggac atcctgcagcgggtgcgagagatccgctaccagggcggcaacaggaccaacactgggctg gccctgcggtacctctctgaccacagcttcttggtcagccagggtgaccgggagcaggcg cccaacctggtctacatggtcaccggaaatcctgcctctgatgagatcaagaggctgcct ggagacatccaggtggtgcccattggagtgggccctaatgccaacgtgcaggagctggag aggattggctggcccaatgcccctatcctcatccaggactttgagacgctcccccgagag gctcctgacctggtgctgcagaggtgctgctccggagaggggctgcagatccccaccctc tcccctgcacctgactgcagccagcccctggacgtgatccttctcctggatggctcctcc agtttcccagcttcttattttgatgaaatgaagagtttcgccaaggctttcatttcaaaa gccaatatagggcctcgtctcactcaggtgtcagtgctgcagtatggaagcatcaccacc attgacgtgccatggaacgtggtcccggagaaagcccatttgctgagccttgtggacgtc atgcagcgggagggaggccccagccaaatcggggatgccttgggctttgctgtgcgatac ttgacttcagaaatgcatggtgccaggccgggagcctcaaaggcggtggtcatcctggtc acggacgtctctgtggattcagtggatgcagcagctgatgccgccaggtccaacagagtg acagtgttccctattggaattggagatcgctacgatgcagcccagctacggatcttggca ggcccagcaggcgactccaacgtggtgaagctccagcgaatcgaagacctccctaccatg gtcaccttgggcaattccttcctccacaaactgtgctctggatttgttaggatttgcatg gatgaggatgggaatgagaagaggcccggggacgtctggaccttgccagaccagtgccac accgtgacttgccagccagatggccagaccttgctgaagagtcatcgggtcaactgtgac cgggggctgaggccttcgtgccctaacagccagtcccctgttaaagtggaagagacctgt ggctgccgctggacctgcccctgcgtgtgcacaggcagctccactcggcacatcgtgacc tttgatgggcagaatttcaagctgactggcagctgttcttatgtcctatttcaaaacaag gagcaggacctggaggtgattctccataatggtgcctgcagccctggagcaaggcagggc tgcatgaaatccatcgaggtgaagcacagtgccctctccgtcgagctgcacagtgacatg gaggtgacggtgaatgggagactggtctctgttccttacgtgggtgggaacatggaagtc aacgtttatggtgccatcatgcatgaggtcagattcaatcaccttggtcacatcttcaca ttcactccacaaaacaatgagttccaactgcagctcagccccaagacttttgcttcaaag acgtatggtctgtgtgggatctgtgatgagaacggagccaatgacttcatgctgagggat ggcacagtcaccacagactggaaaacacttgttcaggaatggactgtgcagcggccaggg cagacgtgccagcccatcctggaggagcagtgtcttgtccccgacagctcccactgccag gtcctcctcttaccactgtttgctgaatgccacaaggtcctggctccagccacattctat gccatctgccagcaggacagttgccaccaggagcaagtgtgtgaggtgatcgcctcttat gcccacctctgtcggaccaacggggtctgcgttgactggaggacacctgatttctgtgct atgtcatgcccaccatctctggtctacaaccactgtgagcatggctgtccccggcactgt gatggcaacgtgagctcctgtggggaccatccctccgaaggctgtttctgccctccagat aaagtcatgttggaaggcagctgtgtccctgaagaggcctgcactcagtgcattggtgag gatggagtccagcaccagttcctggaagcctgggtcccggaccaccagccctgtcagatc tgcacatgcctcagcgggcggaaggtcaactgcacaacgcagccctgccccacggccaaa gctcccacgtgtggcctgtgtgaagtagcccgcctccgccagaatgcagaccagtgctgc cccgagtatgagtgtgtgtgtgacccagtgagctgtgacctgcccccagtgcctcactgt gaacgtggcctccagcccacactgaccaaccctggcgagtgcagacccaacttcacctgc gcctgcaggaaggaggagtgcaaaagagtgtccccaccctcctgccccccgcaccgtttg cccacccttcggaagacccagtgctgtgatgagtatgagtgtgcctgcaactgtgtcaac tccacagtgagctgtccccttgggtacttggcctcaactgccaccaatgactgtggctgt accacaaccacctgccttcccgacaaggtgtgtgtccaccgaagcaccatctaccctgtg ggccagttctgggaggagggctgcgatgtgtgcacctgcaccgacatggaggatgccgtg atgggcctccgcgtggcccagtgctcccagaagccctgtgaggacagctgtcggtcgggc ttcacttacgttctgcatgaaggcgagtgctgtggaaggtgcctgccatctgcctgtgag gtggtgactggctcaccgcggggggactcccagtcttcctggaagagtgtcggctcccag tgggcctccccggagaacccctgcctcatcaatgagtgtgtccgagtgaaggaggaggtc tttatacaacaaaggaacgtctcctgcccccagctggaggtccctgtctgcccctcgggc tttcagctgagctgtaagacctcagcgtgctgcccaagctgtcgctgtgagcgcatggag gcctgcatgctcaatggcactgtcattgggcccgggaagactgtgatgatcgatgtgtgc acgacctgccgctgcatggtgcaggtgggggtcatctctggattcaagctggagtgcagg aagaccacctgcaacccctgccccctgggttacaaggaagaaaataacacaggtgaatgt tgtgggagatgtttgcctacggcttgcaccattcagctaagaggaggacagatcatgaca ctgaagcgtgatgagacgctccaggatggctgtgatactcacttctgcaaggtcaatgag agaggagagtacttctgggagaagagggtcacaggctgcccaccctttgatgaacacaag tgtctggctgagggaggtaaaattatgaaaattccaggcacctgctgtgacacatgtgag gagcctgagtgcaacgacatcactgccaggctgcagtatgtcaaggtgggaagctgtaag tctgaagtagaggtggatatccactactgccagggcaaatgtgccagcaaagccatgtac tccattgacatcaacgatgtgcaggaccagtgctcctgctgctctccgacacggacggag cccatgcaggtggccctgcactgcaccaatggctctgttgtgtaccatgaggttctcaat gccatggagtgcaaatgctcccccaggaagtgcagcaagtga

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