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KEGG   Homo sapiens (human): 2560
Entry
2560              CDS       T01001                                 
Symbol
GABRB1, DEE45, EIEE45
Name
(RefSeq) gamma-aminobutyric acid type A receptor subunit beta1
  KO
K05181  gamma-aminobutyric acid receptor subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555 D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Cipepofol: D12449
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Darigabat: D12146
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279
Gaboxadol: D04282
Ganaxolone: D04300<US>
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP/US> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2560 (GABRB1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2560 (GABRB1)
   04726 Serotonergic synapse
    2560 (GABRB1)
   04723 Retrograde endocannabinoid signaling
    2560 (GABRB1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2560 (GABRB1)
   05033 Nicotine addiction
    2560 (GABRB1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2560 (GABRB1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2560 (GABRB1)
SSDB
Motif
Pfam: Neur_chan_memb Neur_chan_LBD
Other DBs
NCBI-GeneID: 2560
NCBI-ProteinID: NP_000803
OMIM: 137190
HGNC: 4081
Ensembl: ENSG00000163288
UniProt: P18505 X5DNL6
LinkDB
Position
4:46993647..47426447
AA seq 474 aa
MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
NT seq 1425 nt   +upstreamnt  +downstreamnt
atgtggacagtacaaaatcgagagagtctggggcttctctctttccctgtgatgattacc
atggtctgttgtgcacacagcaccaatgaacccagcaacatgtcatacgtgaaagagaca
gtggacagattgctcaaaggatatgacattcgcttgcggccggacttcggagggcccccc
gtcgacgttgggatgcggatcgatgtcgccagcatagacatggtctccgaagtgaatatg
gattatacactcaccatgtatttccagcagtcttggaaagacaaaaggctttcttattct
ggaatcccactgaacctcaccctagacaatagggtagctgaccaactctgggtaccagac
acctactttctgaatgacaagaaatcatttgtgcatggggtcacagtgaaaaatcgaatg
attcgactgcatcctgatggaacagttctctatggactccgaatcacaaccacagctgca
tgtatgatggatcttcgaagatatccattggatgagcagaactgcaccctggagatcgaa
agttatggctataccactgatgacattgaattttactggaatggaggagaaggggcagtc
actggtgttaataaaatcgaacttcctcaattttcaattgttgactacaagatggtgtct
aagaaggtggagttcacaacaggagcgtatccacgactgtcactaagttttcgtctaaag
agaaacattggttacttcattttgcaaacctacatgccttctacactgattacaattctg
tcctgggtgtctttttggatcaactatgatgcatctgcagccagagtcgcactaggaatc
acgacagtgcttacaatgacaaccatcagcacccacctcagggagaccctgccaaagatc
ccttatgtcaaagcgattgatatttatctgatgggttgctttgtgtttgtgttcctggct
ctgctggagtatgcctttgtaaattacatcttctttgggaaaggccctcagaaaaaggga
gctagcaaacaagaccagagtgccaatgagaagaataaactggagatgaataaagtccag
gtcgacgcccacggtaacattctcctcagcaccctggaaatccggaatgagacgagtggc
tcggaagtgctcacgagcgtgagcgaccccaaggccaccatgtactcctatgacagcgcc
agcatccagtaccgcaagcccctgagcagccgcgaggcctacgggcgcgccctggaccgg
cacggggtacccagcaaggggcgcatccgcaggcgtgcctcccagctcaaagtcaagatc
cccgacttgactgatgtgaattccatagacaagtggtcccgaatgtttttccccatcacc
ttttctctttttaatgtcgtctattggctttactatgtacactga

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