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KEGG   DRUG: Temazepam
Entry
D00370                      Drug                                   
Name
Temazepam (USP/INN);
Restoril (TN)
Product
  Generic
TEMAZEPAM (A-S Medication Solutions), TEMAZEPAM (ATLANTIC BIOLOGICALS CORP.), TEMAZEPAM (Actavis Pharma), TEMAZEPAM (Advanced Rx Pharmacy of Tennessee), TEMAZEPAM (Advanced Rx Pharmacy of Tennessee), TEMAZEPAM (Alembic Pharmaceuticals Limited), TEMAZEPAM (Alembic Pharmaceuticals), TEMAZEPAM (Amneal Pharmaceuticals LLC), TEMAZEPAM (Amneal Pharmaceuticals of New York LLC), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Ascend Laboratories), TEMAZEPAM (AvPAK), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Direct Rx), TEMAZEPAM (DirectRX), TEMAZEPAM (Golden State Medical Supply), TEMAZEPAM (Golden State Medical Supply), TEMAZEPAM (Major Pharmaceuticals), TEMAZEPAM (McKesson Corporation dba SKY Packaging), TEMAZEPAM (NuCare Pharmaceuticals), TEMAZEPAM (NuCare Pharmaceuticals), TEMAZEPAM (NuCare Pharmaceuticals), TEMAZEPAM (PD-Rx Pharmaceuticals), TEMAZEPAM (PD-Rx Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Quality Care Products LLC), TEMAZEPAM (REMEDYREPACK), TEMAZEPAM (REMEDYREPACK), TEMAZEPAM (Solco Healthcare U.S.), TEMAZEPAM (Sun Pharmaceutical Industries)
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.74
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG03202  Hypnotic
 DG01567  GABA-A receptor agonist
Remark
Same as: C07125
ATC code: N05CD07
Product: D00370<US>
Efficacy
Minor tranquilizer
  Disease
Insomnia [DS:H01609]
Comment
Temazepam is metabolite of Diazepam.
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD07 Temazepam
      D00370  Temazepam (USP/INN) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Promoting Agents
   GABA Receptor Complexes
    Temazepam
     D00370  Temazepam (USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   D00370  Temazepam
  DG03202  Hypnotic
   D00370  Temazepam
  DG01567  GABA-A receptor agonist
   D00370  Temazepam
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03202  Hypnotic
   D00370  Temazepam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00370  Temazepam (USP/INN) <US>
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D00370
Other DBs
CAS: 846-50-4
PubChem: 7847436
ChEBI: 9435
LigandBox: D00370
NIKKAJI: J7.138B
LinkDB
KCF data

ATOM        21
            1   C2y C    17.3534   -8.3394
            2   C8y C    16.5113   -7.2298
            3   C8y C    16.8465   -5.8730
            4   N1y N    18.1075   -5.2949
            5   N2x N    18.7592   -8.3646
            6   C5x C    19.3611   -5.9172
            7   C1y C    19.6476   -7.2859
            8   C8x C    15.8394   -4.9046
            9   C8x C    14.4974   -5.2927
            10  C8y C    14.1622   -6.6495
            11  C8x C    15.1693   -7.6176
            12  O1a O    20.9788   -7.7230
            13  O5x O    20.4052   -4.9828
            14  X   Cl   12.7974   -7.0439
            15  C8y C    16.7189   -9.5891
            16  C8x C    15.3173   -9.5891
            17  C8x C    14.6173  -10.8016
            18  C8x C    15.3173  -12.0140
            19  C8x C    16.7189  -12.0140
            20  C8x C    17.4189  -10.8016
            21  C1a C    18.1075   -3.8949
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    4  21 1

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