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KEGG   Homo sapiens (human): 155
Entry
155               CDS       T01001                                 
Symbol
ADRB3, BETA3AR
Name
(RefSeq) adrenoceptor beta 3
  KO
K04143  adrenergic receptor beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04714  Thermogenesis
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04970  Salivary secretion
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06529  Thermogenesis
  Element
N01688  ADRB3-UCP1 signaling pathway
Disease
H02106  Genetic obesity
Drug target
Adaprolol maleate: D02765
Alprenolol (DG00303): D01182 D07156
Alprenoxime hydrochloride: D02834
Amibegron (DG01237): D08850 D08851
Arbutamine: D02976
Befunolol (DG01138): D01512 D07496
Beradilol monoethyl maleate: D09843
Bopindolol (DG00310): D01794 D07537
Bufetolol hydrochloride: D01504<JP>
Bunitrolol hydrochloride: D01444
Bupranolol (DG00311): D01454 D07590
Carteolol (DG00308): D00599<JP/US> D07624
Cimaterol: D03502
Cloranolol: D07183
Dexpropranolol hydrochloride: D03729
Diacetolol hydrochloride: D03759
Dibutepinephrine (DG03315): D12934 D12935
Dilevalol hydrochloride: D01906
Dipivefrine (DG01129): D01017 D02349
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP/US> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Etilefrine (DG00210): D01573<JP> D07931
Exaprolol hydrochloride: D04120
Fasobegron: D09344
Flestolol sulfate: D04190
Isoprenaline (DG00211): D01390<JP/US> D02066 D02150<JP> D08090
Levobunolol (DG01136): D01025<JP/US> D08115
Medroxalol (DG01317): D04888 D04889
Mepindolol: D07181
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Metipranolol (DG01137): D02081 D02374
Mirabegron: D09535<JP/US>
Nipradilol: D01691<JP>
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Oxprenolol (DG00304): D01806 D08318
Pamatolol sulfate: D05345
Penbutolol (DG00312): D00602 D08074
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Pindolol: D00513<JP/US>
Propranolol (DG00305): D00483<JP/US> D08443
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Ritobegron ethyl hydrochloride: D09732
Solabegron hydrochloride: D05879
Talibegron hydrochloride: D02702
Talinolol: D07184
Tazolol hydrochloride: D06014
Tertatolol (DG00309): D07182 D08572
Tilisolol (DG01322): D01795 D08598
Tiprenolol hydrochloride: D06162
Tolamolol: D06176
Vibegron: D10433<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    155 (ADRB3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    155 (ADRB3)
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    155 (ADRB3)
   04924 Renin secretion
    155 (ADRB3)
  09154 Digestive system
   04970 Salivary secretion
    155 (ADRB3)
  09159 Environmental adaptation
   04714 Thermogenesis
    155 (ADRB3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    155 (ADRB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    155 (ADRB3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    155 (ADRB3)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv
Other DBs
NCBI-GeneID: 155
NCBI-ProteinID: NP_000016
OMIM: 109691
HGNC: 288
Ensembl: ENSG00000188778
UniProt: P13945 A8KAG8
Structure
LinkDB
Position
8:complement(37962990..37966599)
AA seq 408 aa
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
NT seq 1227 nt   +upstreamnt  +downstreamnt
atggctccgtggcctcacgagaacagctctcttgccccatggccggacctccccaccctg
gcgcccaataccgccaacaccagtgggctgccaggggttccgtgggaggcggccctagcc
ggggccctgctggcgctggcggtgctggccaccgtgggaggcaacctgctggtcatcgtg
gccatcgcctggactccgagactccagaccatgaccaacgtgttcgtgacttcgctggcc
gcagccgacctggtgatgggactcctggtggtgccgccggcggccaccttggcgctgact
ggccactggccgttgggcgccactggctgcgagctgtggacctcggtggacgtgctgtgt
gtgaccgccagcatcgaaaccctgtgcgccctggccgtggaccgctacctggctgtgacc
aacccgctgcgttacggcgcactggtcaccaagcgctgcgcccggacagctgtggtcctg
gtgtgggtcgtgtcggccgcggtgtcgtttgcgcccatcatgagccagtggtggcgcgta
ggggccgacgccgaggcgcagcgctgccactccaacccgcgctgctgtgccttcgcctcc
aacatgccctacgtgctgctgtcctcctccgtctccttctaccttcctcttctcgtgatg
ctcttcgtctacgcgcgggttttcgtggtggctacgcgccagctgcgcttgctgcgcggg
gagctgggccgctttccgcccgaggagtctccgccggcgccgtcgcgctctctggccccg
gccccggtggggacgtgcgctccgcccgaaggggtgcccgcctgcggccggcggcccgcg
cgcctcctgcctctccgggaacaccgggccctgtgcaccttgggtctcatcatgggcacc
ttcactctctgctggttgcccttctttctggccaacgtgctgcgcgccctggggggcccc
tctctagtcccgggcccggctttccttgccctgaactggctaggttatgccaattctgcc
ttcaacccgctcatctactgccgcagcccggactttcgcagcgccttccgccgtcttctg
tgccgctgcggccgtcgcctgcctccggagccctgcgccgccgcccgcccggccctcttc
ccctcgggcgttcctgcggcccggagcagcccagcgcagcccaggctttgccaacggctc
gacggggcttcttggggagtttcttag

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