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PLN (ген)

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/PLN (ген) latin yazuında])
PLN
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген PLN[d][1]
Молекуляр функция enzyme inhibitor activity[d][2], ATPase binding[d][2], calcium channel regulator activity[d][3], связывание с белками плазмы[d][4][5][6], ATPase inhibitor activity[d][3][3][3][…], связывание похожих белков[d][3] һәм гомодимеризация белка[d][3][3]
Күзәнәк компоненты мембрана өлеше[d][3], везикула[d][3], endoplasmic reticulum membrane[d][3], мембрана[d][3][3][7], mitochondrial membranes[d][3], Саркоплазматический ретикулум[d][3][3], эндоплазматик челтәр[3][3], митохондрия[8][9], sarcoplasmic reticulum membrane[d][3][3][3][…], perinuclear region of cytoplasm[d][3], calcium ion-transporting ATPase complex[d][7], митохондрия[3][10] һәм protein-containing complex[d][3]
Биологик процесс Notch signaling pathway[d][3], regulation of ryanodine-sensitive calcium-release channel activity[d][3], negative regulation of calcium ion binding[d][2][7], regulation of cardiac conduction[d][8], regulation of calcium ion transport[d][3][11], negative regulation of catalytic activity[d][2], regulation of heart contraction[d][12][3], regulation of cytosolic calcium ion concentration[d][7], cardiac muscle tissue development[d][3], negative regulation of heart contraction[d][3], response to testosterone[d][3], regulation of the force of heart contraction[d][3][7], regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion[d][3], negative regulation of ATP-dependent activity[d][3][7], regulation of ATPase-coupled calcium transmembrane transporter activity[d][11], regulation of calcium ion import[d][3], response to zinc ion[d][3], cellular calcium ion homeostasis[d][3], regulation of relaxation of cardiac muscle[d][7], negative regulation of calcium ion transmembrane transporter activity[d][2][7], Кан әйләнеше[13], negative regulation of heart rate[d][12], negative regulation of calcium ion import[d][2], response to insulin[d][3], regulation of cardiac muscle cell contraction[d][3][7], negative regulation of ATPase-coupled calcium transmembrane transporter activity[d][7], negative regulation of calcium ion transport[d][7], adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process[d][3], regulation of cardiac muscle cell membrane potential[d][7], regulation of the force of heart contraction by cardiac conduction[d][3], regulation of relaxation of muscle[d][3], negative regulation of calcium ion import into sarcoplasmic reticulum[d][3], protein homooligomerization[d][3], regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum[d][3], relaxation of cardiac muscle[d][14], calcium ion transport[d][3][3], negative regulation of ATPase-coupled calcium transmembrane transporter activity[d][3][7] һәм negative regulation of calcium ion import into sarcoplasmic reticulum[d][3][3][3]
Изображение Gene Atlas
 PLN Викиҗыентыкта

PLN (ген) (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[15][16]

Искәрмәләр

[үзгәртү | вики-текстны үзгәртү]
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Asahi M., Kurzydlowski K., Tada M. et al. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.C200269200 — PMID:12032137
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 3,17 3,18 3,19 3,20 3,21 3,22 3,23 3,24 3,25 3,26 3,27 3,28 3,29 3,30 3,31 3,32 3,33 3,34 3,35 3,36 3,37 3,38 3,39 3,40 3,41 3,42 3,43 3,44 3,45 3,46 3,47 3,48 3,49 GOA
  4. ↑ Barabási A., Taipale M., Weile J. et al. Widespread macromolecular interaction perturbations in human genetic disorders // Cell — Cell Press, Elsevier BV, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.04.013 — PMID:25910212
  5. ↑ Catalucci D. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M412845200 — PMID:15598648
  6. ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier BV, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  7. ↑ 7,00 7,01 7,02 7,03 7,04 7,05 7,06 7,07 7,08 7,09 7,10 7,11 7,12 Trieber C. A., Afara M., Young H. S. Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump // Biochemistry / A. Schepartz — ACS, 2009. — ISSN 0006-2960; 1520-4995; 1943-295X — doi:10.1021/BI900852M — PMID:19708671
  8. ↑ 8,0 8,1 GOA
  9. ↑ Højlund K. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes // Mol. Cell. Proteomics — American Society for Biochemistry and Molecular Biology, 2011. — ISSN 1535-9476; 1535-9484 — doi:10.1074/MCP.M110.000299 — PMID:20833797
  10. ↑ Højlund K. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes // Mol. Cell. Proteomics — American Society for Biochemistry and Molecular Biology, 2011. — ISSN 1535-9476; 1535-9484 — doi:10.1074/MCP.M110.000299 — PMID:20833797
  11. ↑ 11,0 11,1 Trieber C. A. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2012. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M112.360859 — PMID:22427649
  12. ↑ 12,0 12,1 Waggoner J. R. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2006. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.0510519103 — PMID:16432188
  13. ↑ K Otsu, J Fujii, M Periasamy et al. Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes // Genomics / A. Engel — Academic Press, Elsevier BV, 1993. — ISSN 0888-7543; 1089-8646 — doi:10.1006/GENO.1993.1357 — PMID:8406504
  14. ↑ Kranias E. G., Hajjar R. J. Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome // Circ. Res. — Lippincott Williams & Wilkins, 2012. — ISSN 0009-7330; 1524-4571 — doi:10.1161/CIRCRESAHA.111.259754 — PMID:22679139
  15. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  16. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

[үзгәртү | вики-текстны үзгәртү]
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


Миоглобин молекуласы
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