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About: Iomazenil

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Iomazenil (also known as Ro16-0154, INN, USAN; benzodine) is an antagonist and partial inverse agonist of benzodiazepine and a potential treatment for alcohol use disorder. The compound was introduced in 1989 by pharmaceutical company Hoffmann-La Roche as an Iodine-123-labelled SPECT tracer for imaging benzodiazepine receptors (GABAA receptors) in the brain. Iomazenil is an analogue of flumazenil (Ro15-1788).

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dbo:abstract
  • Iomazenil (also known as Ro16-0154, INN, USAN; benzodine) is an antagonist and partial inverse agonist of benzodiazepine and a potential treatment for alcohol use disorder. The compound was introduced in 1989 by pharmaceutical company Hoffmann-La Roche as an Iodine-123-labelled SPECT tracer for imaging benzodiazepine receptors (GABAA receptors) in the brain. Iomazenil is an analogue of flumazenil (Ro15-1788). (en)
  • イオマゼニル (123I) (Iomazenil (123I) )は、ベンゾジアゼピンの遮断薬かつ部分的逆作動薬であり、部分てんかん患者におけるてんかん焦点の診断に使用されている。イオマゼニルは、脳内のベンゾジアゼピン受容体(GABAA受容体)を可視化するためのヨウ素123標識SPECTトレーサーとして1989年に発売された。開発コード:Ro16-0154。イオマゼニルは、フルマゼニル(Ro15-1788)の類縁化合物である。アルコール濫用の治療薬としても期待されている。 (ja)
  • L'iomazenil è uno psicofarmaco appartenente alla categoria delle che è un antagonista e agonista inverso parziale delle benzodiazepine ed è un potenziale trattamento per l'alcolismo. Il farmaco è stato introdotto nel 1989 dalla società farmaceutica Hoffmann-La Roche. Iomazenil è un analogo sia strutturalmente, sia effettivo del flumazenil (Ro15-1788). (it)
  • 碘西尼(Iomazenil)為一種研發中的藥物,能夠阻止酒精對人中樞神經產生的作用。在服用酒精或飲酒前服用碘西尼,能使人保持长时间的清醒。 (zh)
dbo:casNumber
  • (123I)
  • 127985-21-1
dbo:chEMBL
  • 2105020
dbo:chemicalFormula
  • C15H14123IN3O3
dbo:fdaUniiCode
  • 7DVX185FLQ
  • B851121553
dbo:pubchem
  • 65959
dbo:thumbnail
dbo:wikiPageExternalLink
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  • 35855789 (xsd:integer)
dbo:wikiPageLength
  • 5431 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1120163419 (xsd:integer)
dbo:wikiPageWikiLink
dbp:casNumber
  • 127985 (xsd:integer)
dbp:chembl
  • 2105020 (xsd:integer)
dbp:chemicalFormula
  • C15H14123IN3O3 (en)
dbp:chemspiderid
  • 59362 (xsd:integer)
dbp:index2Label
  • 123 (xsd:integer)
dbp:iupacName
  • ethyl 7-iodanyl-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (en)
dbp:molecularWeight
  • 407.290000 (xsd:double)
dbp:pubchem
  • 65959 (xsd:integer)
dbp:smiles
  • CCOCc1c2n-c3ccccI (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • FRIZVHMAECRUBR-KIWWSDKQSA-N (en)
dbp:synonyms
  • Ro 16-0154 (en)
dbp:unii
  • 7 (xsd:integer)
  • B851121553 (en)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Iomazenil (also known as Ro16-0154, INN, USAN; benzodine) is an antagonist and partial inverse agonist of benzodiazepine and a potential treatment for alcohol use disorder. The compound was introduced in 1989 by pharmaceutical company Hoffmann-La Roche as an Iodine-123-labelled SPECT tracer for imaging benzodiazepine receptors (GABAA receptors) in the brain. Iomazenil is an analogue of flumazenil (Ro15-1788). (en)
  • イオマゼニル (123I) (Iomazenil (123I) )は、ベンゾジアゼピンの遮断薬かつ部分的逆作動薬であり、部分てんかん患者におけるてんかん焦点の診断に使用されている。イオマゼニルは、脳内のベンゾジアゼピン受容体(GABAA受容体)を可視化するためのヨウ素123標識SPECTトレーサーとして1989年に発売された。開発コード:Ro16-0154。イオマゼニルは、フルマゼニル(Ro15-1788)の類縁化合物である。アルコール濫用の治療薬としても期待されている。 (ja)
  • L'iomazenil è uno psicofarmaco appartenente alla categoria delle che è un antagonista e agonista inverso parziale delle benzodiazepine ed è un potenziale trattamento per l'alcolismo. Il farmaco è stato introdotto nel 1989 dalla società farmaceutica Hoffmann-La Roche. Iomazenil è un analogo sia strutturalmente, sia effettivo del flumazenil (Ro15-1788). (it)
  • 碘西尼(Iomazenil)為一種研發中的藥物,能夠阻止酒精對人中樞神經產生的作用。在服用酒精或飲酒前服用碘西尼,能使人保持长时间的清醒。 (zh)
rdfs:label
  • Iomazenil (en)
  • Iomazenil (it)
  • イオマゼニル (123I) (ja)
  • 碘西尼 (zh)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
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is dbo:wikiPageWikiLink of
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