Sir George Barne (died 1558) (also called Barons or Barnes) was an English businessman in the City of London who was active in developing new trading links with Russia, West Africa and North America, far outside what had been traditional English trading patterns. Created a knight in 1553, he served as Sheriff of London and Lord Mayor of London. He was the father of Sir George Barne (died 1593) and grandfather of Sir William Barne. Nicholas Culverwell was probably a nephew.