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About: COX-3

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COX-3 is an enzyme that is encoded by the PTGS1 (COX1) gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase (COX) isozyme, the others being COX-1 and COX-2. The COX-3 isozyme is encoded by the same gene as COX-1, with the difference that COX-3 retains an intron that is not retained in COX-1. The other two cyclooxygenase isozymes are known to convert dihomo-γ-linolenic acid and arachidonic acid into prostaglandins, and are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs).

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  • COX-3 is an enzyme that is encoded by the PTGS1 (COX1) gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase (COX) isozyme, the others being COX-1 and COX-2. The COX-3 isozyme is encoded by the same gene as COX-1, with the difference that COX-3 retains an intron that is not retained in COX-1. The other two cyclooxygenase isozymes are known to convert dihomo-γ-linolenic acid and arachidonic acid into prostaglandins, and are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs). (en)
  • La cyclooxygénase 3, ou COX-3, est l'une des trois isoenzymes de la cyclooxygénase, codée chez l'homme par le gène PTGS1 sur le chromosome 1, gène qui code également la cyclooxygénase 1 (COX-1) ; la différence est que la COX-3 conserve un intron qui est éliminé dans la COX-1. La protéine COX-3 n'est pas une enzyme fonctionnelle chez l'homme, tandis que les deux autres cyclooxygénases, COX-1 et COX-2, convertissent l'acide dihomo-γ-linolénique et l'acide arachidonique en prostaglandines, et sont les cibles des anti-inflammatoires non stéroïdiens (AINS). (fr)
  • La COX-3 è, in ordine di scoperta, l'ultima delle forme isoenzimatiche della prostaglandina-endoperossido sintasi, insieme alle altre forme note, COX-1 e COX-2. (it)
  • COX-3 é uma recente descoberta de isoforma de ciclo-oxigenase, encontrada no cérebro, medula espinhal e coração. A estrutura química corresponde a da COX-1, exceto pelo íntron 1. Foi sugerida por Daniel L. Simmons e sua equipe e acredita-se que este tipo esteja presente no sistema nervoso central devido os efeitos do paracetamol (provável inibidor mais seletivo desta forma) e não tanto de COX-2 e COX-1 na periferia. Modula a dor e febre no SNC (pt)
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  • COX-3 is an enzyme that is encoded by the PTGS1 (COX1) gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase (COX) isozyme, the others being COX-1 and COX-2. The COX-3 isozyme is encoded by the same gene as COX-1, with the difference that COX-3 retains an intron that is not retained in COX-1. The other two cyclooxygenase isozymes are known to convert dihomo-γ-linolenic acid and arachidonic acid into prostaglandins, and are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs). (en)
  • La cyclooxygénase 3, ou COX-3, est l'une des trois isoenzymes de la cyclooxygénase, codée chez l'homme par le gène PTGS1 sur le chromosome 1, gène qui code également la cyclooxygénase 1 (COX-1) ; la différence est que la COX-3 conserve un intron qui est éliminé dans la COX-1. La protéine COX-3 n'est pas une enzyme fonctionnelle chez l'homme, tandis que les deux autres cyclooxygénases, COX-1 et COX-2, convertissent l'acide dihomo-γ-linolénique et l'acide arachidonique en prostaglandines, et sont les cibles des anti-inflammatoires non stéroïdiens (AINS). (fr)
  • La COX-3 è, in ordine di scoperta, l'ultima delle forme isoenzimatiche della prostaglandina-endoperossido sintasi, insieme alle altre forme note, COX-1 e COX-2. (it)
  • COX-3 é uma recente descoberta de isoforma de ciclo-oxigenase, encontrada no cérebro, medula espinhal e coração. A estrutura química corresponde a da COX-1, exceto pelo íntron 1. Foi sugerida por Daniel L. Simmons e sua equipe e acredita-se que este tipo esteja presente no sistema nervoso central devido os efeitos do paracetamol (provável inibidor mais seletivo desta forma) e não tanto de COX-2 e COX-1 na periferia. Modula a dor e febre no SNC (pt)
rdfs:label
  • COX-3 (en)
  • Cyclooxygénase 3 (fr)
  • COX-3 (it)
  • COX-3 (pt)
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