LY-487,379
 | |
| IUPAC ime | |
|---|---|
N-(4-(2-metoksifenoksi)fenil)- N-(2,2,2-trifluoroetilsulfonil)pirid- 3-ilmetilamin | |
| Identifikatori | |
| ATC kod | none |
| PubChem | CID 9825084 |
| IUPHAR/BPS | 1402 |
| ChEMBL | CHEMBL108939  |
| Hemijski podaci | |
| Formula | C21H19F3N2O4S |
| Molarna masa | 452,446 g/mol |
| |
LY-487,379 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni pozitivni alosterni modulator za metabotropni glutamatni receptor grupe II mGluR2.[1] On se koristio za studiranje strukture i funkcije ovog tipa receptor,[2][3] i LY-487,379 se zajedno sa drugim mGluR2/3 agonistima i pozitivnim modulatorima istražuje kao mogući antipsihotik i anksiolitik.[4][5][6][7]
Reference
[уреди | уреди извор]- ^ Johnson, M. P.; Baez, M.; Jagdmann Jr, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A.; et al. (2003). „Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine”. Journal of Medicinal Chemistry. 46 (15): 3189—3192. PMID 12852748. doi:10.1021/jm034015u.
- ^ HSchaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G.; et al. (2003). „Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Molecular Pharmacology. 64 (4): 798—810. PMID 14500736. doi:10.1124/mol.64.4.798.
- ^ Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). „Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus”. Neuropharmacology. 49: 57—50. PMID 15993439. doi:10.1016/j.neuropharm.2005.03.006.
- ^ Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). „A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity”. Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181—7. PMID 16123306. doi:10.1124/jpet.105.091074.
- ^ Marino; Conn, P. (2006). „Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors”. Current Opinion in Pharmacology. 6 (1): 98—102. PMID 16368268. doi:10.1016/j.coph.2005.09.006.
- ^ Harich; Gross, G.; Bespalov, A. (2007). „Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment”. Psychopharmacology. 192 (4): 511—519. PMID 17318501. doi:10.1007/s00213-007-0742-y.
- ^ Dillon Ripley (1958). „Extinct and Vanishing Birds of the World”. The Auk. 75 (4): 480—482. JSTOR 4082117. PMID 190790739.
