Bromizoval

Bromizoval
Nazivi
	IUPAC naziv (RS)-2-Bromo-N-karbamoil-3-metilbutanamid
Identifikacija
CAS broj	496-67-3 ; 27109-49-5 R ;
3D model (Jmol)	interaktivna slika; interaktivna slika;
ChemSpider	2353 ; 129594 R ; 643139 S ;
ECHA InfoCard	100.007.115
EC broj	207-825-7
KEGG	D01391;
MeSH	Bromisovalum
PubChem C ID	2447; 146955 R; 735997 S;
UNII	469GW8R486 ;
	SMILES CC(C)C(Br)c(:[o]):[nH]:c(:[nH2]):[o]; CC(C)C(Br)C(=O)NC(N)=O; ; ; ; ;
Svojstva
Hemijska formula	C6H11BrN2O2
Molarna masa	223,07 g·mol−1
log P	1,057
Kiselost (pKa)	10,536
Baznost (pKb)	3;461
Farmakologija
Načini upotrebe	Oralno
Srodna jedinjenja
Srodne ureje	Karbromal
Srodna jedinjenja	3-Ureidopropionska kiselina; beta-Ureidoizobutirinska kiselina; Karbamoil aspartinska kiselina; N-Acetilaspartinska kiselina; Aceglutamid; N-Acetilglutaminska kiselina; Citrulin;
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

Bromizoval (bromvalerilureja) je hipnotik i sedativ koji je bio otkriven 1907.^[4] One je u prodaji na slobodno u Aziji pod mnoštvom naziva (kao što je Brovarin^[5]). On se obično koristi u kombinaciji sa nesteroidnim antiinflamatornim lekovima.

Hronična upotreba bromizovala je vezana za trovanje bromom.^[6]^[7]^[8]^[9]

Reference

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ US patent 914518, Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 09. 03. 1909., assigned to Knoll
^ „Bromisoval”. International. Drugs.com.
^ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (pdf) (на језику: japanese). 38 (5): 700—703. ISSN 0300-9173. PMID 11605223. doi:10.3143/geriatrics.38.700 http://www.jstage.jst.go.jp/article/geriatrics1964/38/5/38_5_700/_pdf |url= захтева наслов (помоћ).
^ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). „Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse” (pdf). Internal Medicine. Tokyo, Japan. 37 (9): 788—791. PMID 9804091. doi:10.2169/internalmedicine.37.788.
^ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). „Pseudohyperchloraemia due to bromvalerylurea abuse”. Nephrology Dialysis Transplantation. 20 (8): 1767—1768. PMID 15972320. doi:10.1093/ndt/gfh945.
^ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). „Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning” (pdf). Internal Medicine. Tokyo, Japan. 36 (10): 742—746. PMID 9372340. doi:10.2169/internalmedicine.36.742.

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Acekarbromal

Spoljašnje veze

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u vezi sa temama iz oblasti medicine (zdravlja).

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] US patent 914518, Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 09. 03. 1909., assigned to Knoll

[5] „Bromisoval”. International. Drugs.com.

[6] Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (pdf) (на језику: japanese). 38 (5): 700—703. ISSN 0300-9173. PMID 11605223. doi:10.3143/geriatrics.38.700 http://www.jstage.jst.go.jp/article/geriatrics1964/38/5/38_5_700/_pdf |url= захтева наслов (помоћ).

[7] Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). „Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse” (pdf). Internal Medicine. Tokyo, Japan. 37 (9): 788—791. PMID 9804091. doi:10.2169/internalmedicine.37.788.

[8] Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). „Pseudohyperchloraemia due to bromvalerylurea abuse”. Nephrology Dialysis Transplantation. 20 (8): 1767—1768. PMID 15972320. doi:10.1093/ndt/gfh945.

[9] Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). „Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning” (pdf). Internal Medicine. Tokyo, Japan. 36 (10): 742—746. PMID 9372340. doi:10.2169/internalmedicine.36.742.

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