1522

1522 (MDXXII) was a common year starting on Wednesday of the Julian calendar, the 1522nd year of the Common Era (CE) and Anno Domini (AD) designations, the 522nd year of the 2nd millennium, the 22nd year of the 16th century, and the 3rd year of the 1520s decade. As of the start of 1522, the Gregorian calendar was 10 days ahead of the Julian calendar, which was the dominant calendar of the time.

• January 9 – Adrian Dedens becomes Pope Adrian VI.
• February 26 – Execution by hanging of Cuauhtémoc, Aztec ruler of Tenochtitlan under orders of conquistador Hernán Cortés.
• April 22 – Battle of Bicocca – French and Swiss forces under Odet de Lautrec are defeated by the Spanish in their attempt to retake Milan, and are forced to withdraw into Venetian territory.
• July 28 – Beginning of Ottoman Sultan Suleiman I's siege of the Knights of St. John in Rhodes.
• September 6 – The Vittoria, one of the surviving ships of Ferdinand Magellan's expedition, returns to Sanlcar de Barrameda in Spain, becoming the first ship to circumnavigate the world.
• December 18 – The Turks finally break into Rhodes, but the Knights continue fierce resistance in the streets.
• December 20 – Suleiman the Magnificent accepts the surrender of the surviving Knights, who are allowed to evacuate. They eventually re-settle on Malta and become known as the Knights of Malta.
• First Diet of Nuremberg.
• The third edition of the Textus Receptus of the Bible published.