Bupropion

Bupropion, also sold as Wellbutrin or Zyban, is an antidepressant. It is also used to help people quit smoking.^[1]^[2] Bupropion is different from other antidepressants because it does not often cause weight gain or sleepiness.^[3] However, it has a higher chance of causing seizures than other antidepressants.

Common side effects of bupropion are having a dry mouth, nausea, lack of sleep, a lot of sweating, anxiety and constipation (difficulty pooping).^[4] It can also increase blood pressure.^[5] Using bupropion while pregnant can give the baby congenital heart defects.

Bupropion was made by Nariman Mehta in 1969. It was first used in the United States in 1985. Bupropion was first called amfebutamone, but it was renamed in 2000.^[6] In 2020, it had more than 25 million prescriptions in the United States.^[7]

References

↑ "Bupropion hydrochloride (Zyban) for quitting smoking". Webmd.com. 2009-07-22. Retrieved 2011-11-04.
↑ Patel, Krisna; Allen, Sophie; Haque, Mariam N.; Angelescu, Ilinca; Baumeister, David; Tracy, Derek K. (April 6, 2016). "Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant". Therapeutic Advances in Psychopharmacology. 6 (2): 99–144. doi:10.1177/2045125316629071. ISSN 2045-1253. PMC 4837968. PMID 27141292.
↑ Dhillon, Sohita; Yang, Lily P. H.; Curran, Monique P. (2008). "Bupropion: a review of its use in the management of major depressive disorder". Drugs. 68 (5): 653–689. doi:10.2165/00003495-200868050-00011. ISSN 0012-6667. PMID 18370448. S2CID 195687060.
↑ . 2011-07-17 https://web.archive.org/web/20110717003144/http://us.gsk.com/products/assets/us_wellbutrinXL.pdf. Archived from the original (PDF) on 2011-07-17. Retrieved 2022-11-17. {{cite web}}: Missing or empty |title= (help)
↑ Wilens, Timothy E.; Hammerness, Paul G.; Biederman, Joseph; Kwon, Anne; Spencer, Thomas J.; Clark, Sarah; Scott, Megan; Podolski, Amy; Ditterline, Jeffrey W.; Morris, Matthew C.; Moore, Hadley (February 2005). "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder". The Journal of Clinical Psychiatry. 66 (2): 253–259. doi:10.4088/jcp.v66n0215. ISSN 0160-6689. PMID 15705013.
↑ "International nonproprietary names for pharmaceutical substances (INN) : proposed international nonproprietary names : list 83 = Dénominations communes internationales des substances pharmaceutiques (DCI) : dénominations communes internationales proposées : liste 83 = Denominaciones comunes internacionales para las sustancias farmacéuticas (DCI) : denominaciones comunes internacionales propuestas : lista 83". WHO Drug Information 2000 ; 14(2) : 107-143. 2000. hdl:10665/58135.
↑ "The Top 300 of 2020". clincalc.com. Retrieved 2022-11-17.

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[1] "Bupropion hydrochloride (Zyban) for quitting smoking". Webmd.com. 2009-07-22. Retrieved 2011-11-04.

[2] Patel, Krisna; Allen, Sophie; Haque, Mariam N.; Angelescu, Ilinca; Baumeister, David; Tracy, Derek K. (April 6, 2016). "Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant". Therapeutic Advances in Psychopharmacology. 6 (2): 99–144. doi:10.1177/2045125316629071. ISSN 2045-1253. PMC 4837968. PMID 27141292.

[3] Dhillon, Sohita; Yang, Lily P. H.; Curran, Monique P. (2008). "Bupropion: a review of its use in the management of major depressive disorder". Drugs. 68 (5): 653–689. doi:10.2165/00003495-200868050-00011. ISSN 0012-6667. PMID 18370448. S2CID 195687060.

[4] . 2011-07-17 https://web.archive.org/web/20110717003144/http://us.gsk.com/products/assets/us_wellbutrinXL.pdf. Archived from the original (PDF) on 2011-07-17. Retrieved 2022-11-17. {{cite web}}: Missing or empty |title= (help)

[5] Wilens, Timothy E.; Hammerness, Paul G.; Biederman, Joseph; Kwon, Anne; Spencer, Thomas J.; Clark, Sarah; Scott, Megan; Podolski, Amy; Ditterline, Jeffrey W.; Morris, Matthew C.; Moore, Hadley (February 2005). "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder". The Journal of Clinical Psychiatry. 66 (2): 253–259. doi:10.4088/jcp.v66n0215. ISSN 0160-6689. PMID 15705013.

[6] "International nonproprietary names for pharmaceutical substances (INN) : proposed international nonproprietary names : list 83 = Dénominations communes internationales des substances pharmaceutiques (DCI) : dénominations communes internationales proposées : liste 83 = Denominaciones comunes internacionales para las sustancias farmacéuticas (DCI) : denominaciones comunes internacionales propuestas : lista 83". WHO Drug Information 2000 ; 14(2) : 107-143. 2000. hdl:10665/58135.

[7] "The Top 300 of 2020". clincalc.com. Retrieved 2022-11-17.

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v t e Phenethylamines
Phenethylamines	Psychedelics: 25B-NBOMe 25C-NBOMe 25D-NBOMe 25I-NBOMe 25N-NBOMe 2C-B 2C-B-AN 2C-Bn 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-G 2C-G-1 2C-G-2 2C-G-3 2C-G-4 2C-G-5 2C-G-6 2C-G-N 2C-H 2C-I 2C-iP 2C-N 2C-NH2 2C-O 2C-O-4 2C-P 2C-Ph 2C-SE 2C-T 2C-T-2 2C-T-3 2C-T-4 2C-T-5 2C-T-6 2C-T-7 2C-T-8 2C-T-9 2C-T-10 2C-T-11 2C-T-12 2C-T-13 2C-T-14 2C-T-15 2C-T-16 2C-T-17 2C-T-18 2C-T-19 2C-T-20 2C-T-21 2C-T-22 2C-T-22.5 2C-T-23 2C-T-24 2C-T-25 2C-T-27 2C-T-28 2C-T-30 2C-T-31 2C-T-32 2C-T-33 2C-TFE 2C-TFM 2C-YN 2C-V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi-2C-T-4 TCB-2 Stimulants: Phenylethanolamine Hordenine Phenethylamine Phenpromethamine α-Methylphenethylamine (amphetamine) β-Methylphenethylamine m-Methylphenethylamine N-Methylphenethylamine o-Methylphenethylamine p-Methylphenethylamine Methylphenidate Entactogens: Lophophine MDPEA MDMPEA Others: BOH DMPEA
Amphetamines	Psychedelics: 3C-AL 3C-BZ 3C-E 3C-MAL 3C-P Aleph Beatrice Bromo-DragonFLY D-Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA-2 Psi-DOM TMA TeMA ZDCM-04 Stimulants: 2-FA 2-FMA 3-FA 3-FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine (Dextroamphetamine, Levoamphetamine) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine (Dexfenfluramine, Levofenfluramine) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4-Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine (Dextromethamphetamine, Levomethamphetamine) Methoxyphenamine MMA Morforex Norfenfluramine L-Norpseudoephedrine N,alpha-Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens: 4-FA 4-FMA 4-MA 4-MMA 4-MTA 5-APB 5-APDB 5-EAPB 5-IT 5-MAPB 5-MAPDB 6-APB 6-APDB 6-Chloro-MDMA 6-EAPB 6-IT 6-MAPB 6-MAPDB EDA IAP 2,3-MDA 3,4-MDA (tenamfetamine) MDEA MDHMA MDMA (midomafetamine) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others: 3,4-DCA Amiflamine DiFMDA Selegiline (also D-Deprenyl)
Phentermines	Stimulants: Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens: MDPH MDMPH Others: Cericlamine
Cathinones	Stimulants: 3-FMC 4-MC 4-BMC 4-CMC 4-EMC 4-FMC 4-MEC 4-MeMABP 4-MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB N-Ethylhexedrone N-Ethylpentedrone Pentedrone Pentylone Radafaxine Entactogens: 3,4-DMMC 3-MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone
Phenylisobutylamines	Entactogens: 4-CAB 4-MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines	Stimulants: α-PBP α-PHP α-PPP α-PVP MDPBP MDPPP MDPV 4-MePBP 4-MePHP 4-MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone
Catecholamines (and close relatives)	6-FNE 6-OHDA a-Me-DA a-Me-TRA Adrenochrome Ciladopa D-DOPA (Dextrodopa) Dimetofrine Dopamine Epinephrine Epinine Etilefrine Ethylnorepinephrine Fenclonine Ibopamine Isoprenaline Isoetarine L-DOPA (Levodopa) L-DOPS (Droxidopa) L-Phenylalanine L-Tyrosine m-Tyramine Metanephrine Metaraminol Metaterol Metirosine Methyldopa N,N-Dimethyldopamine Nordefrin (Levonordefrin) Norepinephrine Norfenefrine (m-Octopamine) Normetanephrine Orciprenaline p-Octopamine p-Tyramine Phenylephrine Synephrine