Hinuklidin

Hinuklidin
Skeletal formula of quinuclidine	Ball-and-stick model of quinuclidine
	1-Azabicyclo[2.2.2]octane
Identifikacija
CAS registarski broj	100-76-5
PubChem	7527
ChemSpider	7246
ChEMBL	CHEMBL1209648
Jmol-3D slike	Slika 1
SMILES
	N12CCC(CC1)CC2
InChI
	InChI=1S/C7H13N/c1-4-8-5-2-7(1)3-6-8/h7H,1-6H2 ; Kod: SBYHFKPVCBCYGV-UHFFFAOYSA-N InChI=1/C7H13N/c1-4-8-5-2-7(1)3-6-8/h7H,1-6H2; Kod: SBYHFKPVCBCYGV-UHFFFAOYAA
Svojstva
Molekulska formula	C7H13N
Molarna masa	111.18 g/mol
Tačka topljenja	157–160 °C
pKa	11.0 (konjugovane kiseline)
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Hinuklidin je organsko jedinjenje i biciklični amin koji se koristi kao katalizator i hemijski gradivni blok. On je jaka baza sa pKa vrednošću konjugovane baze od 11.0.^[6] On može da bude pripremljen redukcijom hinuklidona.

Ovo jedinjenje je strukturno srodno sa DABCO-om kod koga je drugi premošteni atom takođe azot, i sa tropanom koji ima malo drugačiji ugljenični okvir.

Hinuklidin je strukturna komponenta niza biomolekula, kao što je hinin.

Literatura

↑ „22709 Quinuclidine purum, ≥97.0% (NT)”. Pristupljeno 17. 04. 2011. ^{[mrtav link]}
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Hext, N. M.; Hansen, J.; Blake, A. J.; Hibbs, D. E.; Hursthouse, M. B.; Shishkin, O. V.; Mascal, M. (1998). „Azatriquinanes: Synthesis, Structure, and Reactivity”. J. Org. Chem. 63 (17): 6016–6020. DOI:10.1021/jo980788s. PMID 11672206.

Spoljašnje veze

Portal Hemija

[url22709_Quinuclidine-1] „22709 Quinuclidine purum, ≥97.0% (NT)”. Pristupljeno 17. 04. 2011. ^{[mrtav link]}

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Hext, N. M.; Hansen, J.; Blake, A. J.; Hibbs, D. E.; Hursthouse, M. B.; Shishkin, O. V.; Mascal, M. (1998). „Azatriquinanes: Synthesis, Structure, and Reactivity”. J. Org. Chem. 63 (17): 6016–6020. DOI:10.1021/jo980788s. PMID 11672206.

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