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{{PBB|geneid=3303}}
'''HSPA1A''', ''protein toplotnog šoka 70 kDa 1'', je [[protein]] koji je kod čoveka kodiran ''HSPA1A'' [[gen]]om.

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Ovaj gen ne sadrži [[intron]]e. On je član familije proteina toplotnog šoka 70. Zajedno s drugim proteinima toplotnog šoka, ovaj protein sprečava agregaciju postojećih proteina i posreduje savijanje novo [[Translacija (genetika)|transliranih]] proteina u [[citosol]]u i [[organela]]ma. On takođe učestvuje u ubikvitin-proteasom putu tako što ostvaruje interakcije sa AU-bogatim elementom RNK-vezujućeg proteina 1. Ovaj gen je lociran u regionu klase III glavnog histokompatibilnostnog kompleksa, u klasteru sa dva blisko srodna gena koji kodiraju slične proteine.<ref name="entrez">{{cite web | title = Entrez Gene: HSPA1A heat shock 70kDa protein 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3303| accessdate = }}</ref>
}}

== Interakcije ==
Za HSPA1A je bilo pokazano da [[Protein-protein interakcija|interaguje]] sa [[ASK1]],<ref name=pmid12391142>{{cite journal |doi=10.1128/MCB.22.22.7721-7730.2002 |last=Park |first=Hee-Sae |authorlink= |coauthors=Cho Ssang-Goo, Kim Chang Kyun, Hwang Hyun Sub, Noh Kyung Tae, Kim Mi-Sung, Huh Sung-Ho, Kim Myung Jin, Ryoo Kanghyun, Kim Eun Kyung, Kang Woo Jin, Lee Jae-Seon, Seo Jeong-Sun, Ko Young-Gyu, Kim Sunghoon, Choi Eui-Ju |year= 2002 |month=November |title=Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1 |journal=Mol. Cell. Biol. |volume=22 |issue=22 |pages=7721–30 |publisher= |location = United States| issn = 0270-7306| pmid = 12391142 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2002-11_22_22/page/7721| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=134722 }}</ref> [[STUB1]],<ref name=pmid10330192>{{cite journal |last=Ballinger |first=C A |authorlink= |coauthors=Connell P, Wu Y, Hu Z, Thompson L J, Yin L Y, Patterson C |year= 1999 |month=June |title=Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions |journal=Mol. Cell. Biol. |volume=19 |issue=6 |pages=4535–45 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10330192 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_1999-06_19_6/page/4535| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=104411 }}</ref><ref name=pmid12150907>{{cite journal |doi=10.1016/S1097-2765(02)00583-X |last=Imai |first=Yuzuru |authorlink= |coauthors=Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke |year= 2002 |month=July |title=CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity |journal=Mol. Cell |volume=10 |issue=1 |pages=55–67 |publisher= |location = United States| issn = 1097-2765| pmid = 12150907 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MSR1]],<ref name=pmid11785981>{{cite journal |last=Nakamura |first=Toshinobu |authorlink= |coauthors=Hinagata Jun-ichi, Tanaka Toshiki, Imanishi Takeshi, Wada Youichiro, Kodama Tatsuhiko, Doi Takefumi |year= 2002 |month=January |title=HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue=2 |pages=858–64 |publisher= |location = United States| issn = 0006-291X| pmid = 11785981 |doi = 10.1006/bbrc.2001.6271 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[BAG3]],<ref name=pmid10980614>{{cite journal |last=Doong |first=H |authorlink= |coauthors=Price J, Kim Y S, Gasbarre C, Probst J, Liotta L A, Blanchette J, Rizzo K, Kohn E |year= 2000 |month=September |title=CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70 |journal=Oncogene |volume=19 |issue=38 |pages=4385–95 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10980614 |doi = 10.1038/sj.onc.1203797 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11527400>{{cite journal |last=Antoku |first=K |authorlink= |coauthors=Maser R S, Scully W J, Delach S M, Johnson D E |year= 2001 |month=September |title=Isolation of [[Bcl-2]] binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue=5 |pages=1003–10 |publisher= |location = United States| issn = 0006-291X| pmid = 11527400 |doi = 10.1006/bbrc.2001.5512 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Parkinova (ligaza)|Parkinovom ligazom]],<ref name=pmid12150907/> [[Fankonijeva anemija, komplementaciona grupa C]],<ref name=pmid12397061>{{cite journal |last=Pang |first=Qishen |authorlink= |coauthors=Christianson Tracy A, Keeble Winifred, Koretsky Tara, Bagby Grover C |year= 2002 |month=December |title=The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49638–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12397061 |doi = 10.1074/jbc.M209386200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid14499622>{{cite journal |doi=10.1016/S0014-4827(03)00261-1 |last=Reuter |first=Tanja Y |authorlink= |coauthors=Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J |year= 2003 |month=October |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport |journal=Exp. Cell Res. |volume=289 |issue=2 |pages=211–21 |publisher= |location = United States| issn = 0014-4827| pmid = 14499622 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GPR37]],<ref name=pmid12150907/> [[HSF1]]<ref name=pmid9499401>{{cite journal |last=Shi |first=Y |authorlink= |coauthors=Mosser D D, Morimoto R I |year= 1998 |month=March |title=Molecular chaperones as HSF1-specific transcriptional repressors |journal=Genes Dev. |volume=12 |issue=5 |pages=654–66 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9499401 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=316571 }}</ref><ref name=pmid9699716>{{cite journal |last=Zhou |first=X |authorlink= |coauthors=Tron V A, Li G, Trotter M J |year= 1998 |month=August |title=Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light |journal=J. Invest. Dermatol. |volume=111 |issue=2 |pages=194–8 |publisher= |location = UNITED STATES| issn = 0022-202X| pmid = 9699716 |doi = 10.1046/j.1523-1747.1998.00266.x | bibcode = | oclc =| id = | url =https://archive.org/details/sim_journal-of-investigative-dermatology_1998-08_111_2/page/194| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> i [[AIFM1]].<ref name=pmid12930708>{{cite journal |last=Ruchalski |first=Kathleen |authorlink= |coauthors=Mao Haiping, Singh Satish K, Wang Yihan, Mosser Dick D, Li Fanghong, Schwartz John H, Borkan Steven C |year= 2003 |month=December |title=HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue=6 |pages=C1483–93 |publisher= |location = United States| issn = 0363-6143| pmid = 12930708 |doi = 10.1152/ajpcell.00049.2003 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11533664>{{cite journal |last=Ravagnan |first=L |authorlink= |coauthors=Gurbuxani S, Susin S A, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger J M, Garrido C, Kroemer G |year= 2001 |month=September |title=Heat-shock protein 70 antagonizes apoptosis-inducing factor |journal=Nat. Cell Biol. |volume=3 |issue=9 |pages=839–43 |publisher= |location = England| issn = 1465-7392| pmid = 11533664 |doi = 10.1038/ncb0901-839 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988  }}
*{{cite journal  | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
*{{cite journal  | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=  }}
*{{cite journal  | author=Muthumani K, Choo AY, Premkumar A, ''et al.'' |title=Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.  | series=12 |journal=Cell Death Differ. |volume=Suppl 1 |issue=  |pages= 962–70 |year= 2006 |pmid= 15832179 |doi= 10.1038/sj.cdd.4401583 }}
*{{cite journal  | author=Grosz MD, Womack JE, Skow LC |title=Syntenic conservation of HSP70 genes in cattle and humans. |journal=Genomics |volume=14 |issue= 4 |pages= 863–8 |year= 1993 |pmid= 1478667 |doi=10.1016/S0888-7543(05)80106-5  }}
*{{cite journal  | author=Veldscholte J, Berrevoets CA, Brinkmann AO, ''et al.'' |title=Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation. |journal=Biochemistry |volume=31 |issue= 8 |pages= 2393–9 |year= 1992 |pmid= 1540595 |doi=10.1021/bi00123a026  }}
*{{cite journal  | author=Abravaya K, Myers MP, Murphy SP, Morimoto RI |title=The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. | url=https://archive.org/details/sim_genes-development_1992-07_6_7/page/1153 |journal=Genes Dev. |volume=6 |issue= 7 |pages= 1153–64 |year= 1992 |pmid= 1628823 |doi=10.1101/gad.6.7.1153  }}
*{{cite journal  | author=Milner CM, Campbell RD |title=Structure and expression of the three MHC-linked HSP70 genes. | url=https://archive.org/details/sim_immunogenetics_1990-10_32_4/page/242 |journal=Immunogenetics |volume=32 |issue= 4 |pages= 242–51 |year= 1990 |pmid= 1700760 |doi=10.1007/BF00187095  }}
*{{cite journal  | author=Sargent CA, Dunham I, Trowsdale J, Campbell RD |title=Human major histocompatibility complex contains genes for the major heat shock protein HSP70. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 6 |pages= 1968–72 |year= 1989 |pmid= 2538825 |doi=10.1073/pnas.86.6.1968  | pmc=286826  }}
*{{cite journal  | author=Wu B, Hunt C, Morimoto R |title=Structure and expression of the human gene encoding major heat shock protein HSP70. | url=https://archive.org/details/sim_molecular-and-cellular-biology_1985-02_5_2/page/330 |journal=Mol. Cell. Biol. |volume=5 |issue= 2 |pages= 330–41 |year= 1985 |pmid= 2858050 |doi=  | pmc=366716  }}
*{{cite journal  | author=Goate AM, Cooper DN, Hall C, ''et al.'' |title=Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis. | url=https://archive.org/details/sim_human-genetics_1987-02_75_2/page/123 |journal=Hum. Genet. |volume=75 |issue= 2 |pages= 123–8 |year= 1987 |pmid= 2880793 |doi=10.1007/BF00591072  }}
*{{cite journal  | author=Hickey E, Brandon SE, Sadis S, ''et al.'' |title=Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia. | url=https://archive.org/details/sim_gene_1986_43_1-2/page/147 |journal=Gene |volume=43 |issue= 1-2 |pages= 147–54 |year= 1986 |pmid= 3019832 |doi=10.1016/0378-1119(86)90018-1  }}
*{{cite journal  | author=Harrison GS, Drabkin HA, Kao FT, ''et al.'' |title=Chromosomal location of human genes encoding major heat-shock protein HSP70. |journal=Somat. Cell Mol. Genet. |volume=13 |issue= 2 |pages= 119–30 |year= 1987 |pmid= 3470951 |doi=10.1007/BF01534692  }}
*{{cite journal  | author=Drabent B, Genthe A, Benecke BJ |title=In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells. |journal=Nucleic Acids Res. |volume=14 |issue= 22 |pages= 8933–48 |year= 1987 |pmid= 3786141 |doi=10.1093/nar/14.22.8933  | pmc=311921  }}
*{{cite journal  | author=Hunt C, Morimoto RI |title=Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 19 |pages= 6455–9 |year= 1985 |pmid= 3931075 |doi=10.1073/pnas.82.19.6455  | pmc=390735  }}
*{{cite journal  | author=Liao J, Lowthert LA, Ghori N, Omary MB |title=The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 915–22 |year= 1995 |pmid= 7529764 |doi=10.1074/jbc.270.2.915  }}
*{{cite journal  | author=Selkirk JK, Merrick BA, Stackhouse BL, He C |title=Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line. |journal=Appl. Theor. Electrophor. |volume=4 |issue= 1 |pages= 11–8 |year= 1995 |pmid= 7811761 |doi=  }}
*{{cite journal  | author=Furlini G, Vignoli M, Re MC, ''et al.'' |title=Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein.  | series=75 |journal=J. Gen. Virol. |volume=(Pt 1) |issue=  1|pages= 193–9 |year= 1994 |pmid= 7906708 |doi=10.1099/0022-1317-75-1-193  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Prapapanich V, Chen S, Toran EJ, ''et al.'' |title=Mutational analysis of the hsp70-interacting protein Hip. | url=https://archive.org/details/sim_molecular-and-cellular-biology_1996-11_16_11/page/6200 |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6200–7 |year= 1996 |pmid= 8887650 |doi=  | pmc=231623  }}
}}
{{refend}}

== Povezano ==
* [[Proteini toplotnog šoka]]
* [[Hsp70]]

== Spoljašnje veze ==
* {{MeshName|HSPA1A+protein,+human}}
{{-}}
{{Posttranslaciona modifikacija-lat}}
{{PDB Galerija-lat|geneid=3303}}

[[Kategorija:Proteini toplotnog šoka]]

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