Abstract
Piwi proteins, a subfamily of Argonaute (Ago) proteins, have recently been shown to bind endogenous small RNAs. However, differences between Ago proteins (which bind microRNAs and small interfering RNAs) and Piwi proteins and Piwi-interacting RNAs (piRNAs) suggest novel functions for Piwi proteins. Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Epigenesis, Genetic
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Female
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Gene Silencing
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Germ Cells / cytology
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Germ Cells / metabolism
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Humans
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Male
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Models, Biological
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Phylogeny
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Proteins / classification
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Proteins / genetics
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Proteins / metabolism*
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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Stem Cells / cytology
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Stem Cells / metabolism
Substances
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MicroRNAs
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Proteins
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RNA, Small Interfering