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Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo

J Cell Sci. 2002 Jun 1;115(Pt 11):2271-82. doi: 10.1242/jcs.115.11.2271.

Abstract

Rho-binding kinase and myosin phosphatase regulate the contraction of actomyosin filaments in non-muscle and smooth muscle cells. Previously, we described the role of C. elegans genes encoding Rho-binding kinase (let-502) and myosin phosphatase targeting subunit (mel-11) in epidermal cell-shape changes that drive morphogenesis and in spermathecal contraction. Here we analyze their roles in a third contractile event, cytokinesis within early embryos. We demonstrate that these genes function together to regulate the rate of cleavage furrow contraction, with Rho-binding kinase/LET-502 mediating contraction, whereas myosin phosphatase/MEL-11 acts as a brake to contraction: early embryonic cleavage often fails or is slowed when let-502 is mutated, whereas mel-11 mutations result in ectopic furrowing and faster furrow ingression. These phenotypes correspond to changes in the levels of phosphorylated regulatory non-muscle myosin light chain (rMLC). The gene products of let-502 and mel-11 colocalize at cleavage furrows, and their mutations alleviate one another's defects. rMLC is phosphorylated in let-502; mel-11 double mutants, indicating that a kinase is able to phosphorylate rMLC in the absence of both LET-502 and MEL-11. Genetic and molecular epistasis experiments place LET-502 and MEL-11 in a cytokinetic pathway. LET-502 and MEL-11 regulate the activity of non-muscle myosin after actin, non-muscle myosin heavy chain/NMY-2, regulatory non-muscle myosin light chain/MLC-4 and early formin/CYK-1 have formed a contractile ring. Proteins including Rho GTPase activating protein/CYK-4 and late CYK-1, which are required for late stages of cytokinesis, function downstream of LET-502 and MEL-11.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / enzymology*
  • Caenorhabditis elegans Proteins*
  • Cell Division / genetics*
  • Cell Movement / genetics
  • Embryo, Nonmammalian / cytology
  • Embryo, Nonmammalian / embryology*
  • Embryo, Nonmammalian / enzymology*
  • Gene Expression Regulation, Developmental / genetics*
  • Helminth Proteins / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Mutation / genetics
  • Myosin Heavy Chains / metabolism
  • Myosin Light Chains / metabolism
  • Myosin-Light-Chain Phosphatase
  • Phenotype
  • Phosphoprotein Phosphatases / genetics
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction / genetics
  • rho-Associated Kinases

Substances

  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Intracellular Signaling Peptides and Proteins
  • Myosin Light Chains
  • cyk-1 protein, C elegans
  • LET-502 protein, C elegans
  • Protein Serine-Threonine Kinases
  • rho-Associated Kinases
  • Phosphoprotein Phosphatases
  • Myosin-Light-Chain Phosphatase
  • Myosin Heavy Chains