Abstract
Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3' Untranslated Regions*
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5' Untranslated Regions
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Amino Acid Motifs
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Animals
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Base Sequence
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Caenorhabditis elegans / genetics
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Drosophila / genetics
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MicroRNAs
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Molecular Sequence Data
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Nucleic Acid Hybridization
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RNA, Antisense / chemistry*
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RNA, Antisense / genetics*
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RNA, Untranslated / chemistry*
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RNA, Untranslated / genetics*
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Sequence Homology, Amino Acid
Substances
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3' Untranslated Regions
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5' Untranslated Regions
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MicroRNAs
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RNA, Antisense
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RNA, Untranslated