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Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

Nat Genet. 2002 Apr;30(4):363-4. doi: 10.1038/ng865. Epub 2002 Mar 18.

Abstract

Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions*
  • 5' Untranslated Regions
  • Amino Acid Motifs
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / genetics
  • Drosophila / genetics
  • MicroRNAs
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • RNA, Antisense / chemistry*
  • RNA, Antisense / genetics*
  • RNA, Untranslated / chemistry*
  • RNA, Untranslated / genetics*
  • Sequence Homology, Amino Acid

Substances

  • 3' Untranslated Regions
  • 5' Untranslated Regions
  • MicroRNAs
  • RNA, Antisense
  • RNA, Untranslated