[go: up one dir, main page]

Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis

Curr Opin Lipidol. 2000 Jun;11(3):267-75. doi: 10.1097/00041433-200006000-00007.

Abstract

In the past several years significant advances have been made in our understanding of lecithin-cholesterol acyltransferase (LCAT) function. LCAT beneficially alters the plasma concentrations of apolipoprotein B-containing lipoproteins, as well as HDL. In addition, its proposed role in facilitating reverse cholesterol transport and modulating atherosclerosis has been demonstrated in vivo. Analysis of LCAT transgenic animals has established the importance of evaluating HDL function, as well as HDL plasma levels, to predict atherogenic risk.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / blood*
  • Biological Transport
  • Cholesterol / blood*
  • Gene Transfer Techniques
  • Glomerulosclerosis, Focal Segmental / enzymology
  • Humans
  • Lipoproteins / blood*
  • Phosphatidylcholine-Sterol O-Acyltransferase / blood
  • Phosphatidylcholine-Sterol O-Acyltransferase / genetics
  • Phosphatidylcholine-Sterol O-Acyltransferase / metabolism*

Substances

  • Lipoproteins
  • Cholesterol
  • Phosphatidylcholine-Sterol O-Acyltransferase