(Q39956580)

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Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662697%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis (English)

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11 January 2020

viral RNA synthesis

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viral rna synthesis

13 November 2022

Esteban Domingo Solans

8

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11 January 2020

2

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11 January 2020

3

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11 January 2020

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11 January 2020

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11 January 2020

Cristina Escarmís

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Cristina Escarmís

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11 January 2020

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Rubén Agudo

1

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11 January 2020

Anabel Marina

7

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11 January 2020

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17 July 2008

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11 January 2020

Journal of Molecular Biology

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11 January 2020

382

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11 January 2020

3

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11 January 2020

652-666

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11 January 2020

Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

2 references

https://opencitations.net/index/api/v1/citations/10.1128/JVI.75.20.9723-9730.2001

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Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus

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https://opencitations.net/index/api/v1/citations/10.1128/JVI.77.12.7131-7138.2003

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Action of mutagenic agents and antiviral inhibitors on foot-and-mouth disease virus.

2 references

https://opencitations.net/index/api/v1/citations/10.1016/J.VIRUSRES.2004.11.008

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On the fidelity of DNA replication: manganese mutagenesis in vitro.

1 reference

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Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe

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Evolutionary transition toward defective RNAs that are infectious by complementation.

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High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies

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Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV).

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Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub)

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Inhibition of replication of rinderpest virus by 5-fluorouracil

1 reference

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What is a quasispecies?

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5-Fluorouracil: mechanisms of action and clinical strategies

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Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe

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Genetic lesions associated with Muller's ratchet in an RNA virus.

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Error catastrophe and antiviral strategy

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection

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Sequential structures provide insights into the fidelity of RNA replication

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Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination

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Manganese-Dependent Polioviruses Caused by Mutations within the Viral Polymerase

1 reference

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Cell entry and export of nucleoside analogues

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Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese

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Viral error catastrophe by mutagenic nucleosides

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An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

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Metabolism and mechanism of action of 5-fluorouracil

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Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity

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Studies on the incorporation of 5-fluorouracil into a virus nucleic acid

1 reference

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The error threshold

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Antiviral strategy on the horizon

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Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development

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The structure of a protein primer-polymerase complex in the initiation of genome replication

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Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA.

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Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding

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Preextinction viral RNA can interfere with infectivity

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Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity

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Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus

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Challenges for the development of ribonucleoside analogues as inducers of error catastrophe

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The incorporation of 5-fluoro-uracil into poliovirus

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Self-replication with errors. A model for polynucleotide replication.

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Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket

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Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies

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Protein Chemical Studies of two RNA Viruses and their Mutants

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Mutation rates among RNA viruses

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Suppression of viral infectivity through lethal defection

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Proposal for a common nomenclature for sequence ions in mass spectra of peptides

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Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

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