(Q36639785)

15 August 2017

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title

Metabolism and mechanism of action of 5-fluorouracil (English)

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15 August 2017

1 reference

https://api.crossref.org/works/10.1016/0163-7258(90)90056-8

4 November 2022

W. B. Parker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1707544

4 November 2022

Y. C. Cheng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1707544

4 November 2022

language of work or name

1 reference

1 January 1990

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full work available at URL

15 August 2017

https://api.elsevier.com/content/article/PII:0163725890900568?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0163-7258(90)90056-8

https://api.elsevier.com/content/article/PII:0163725890900568?httpAccept=text/plain

4 November 2022

1 reference

https://api.crossref.org/works/10.1016/0163-7258(90)90056-8

Pharmacology & Therapeutics

4 November 2022

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

381-395

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An update on the biochemistry of 5-fluorouracil

15 August 2017

cites work

1 reference

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Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-l-aspartate on cell growth and ribonucleic acid synthesis in a human mammary carcinoma

4 November 2022

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The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells

4 November 2022

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Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

4 November 2022

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Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase

4 November 2022

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Thymidylate synthetase - substrate complex formation

4 November 2022

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The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.

4 November 2022

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Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells

4 November 2022

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Determination of three different pools of reduced one-carbon-substituted folates. II. Quantitation and chain-length determination of the pteroylpolyglutamates of rat liver

4 November 2022

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Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells

4 November 2022

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Analysis of the effect of 5-fluorouracil on the synthesis and translation of polysomal poly(A)RNA from Ehrlich ascites cells

4 November 2022

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Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture

4 November 2022

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The Carbon-Fluorine Bond in Compounds of Biological Interest

4 November 2022

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Enhancement of 5-fluorouracil's anticancer activity by dipyridamole

4 November 2022

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Enzymes involved in the repair of damaged DNA

4 November 2022

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Circadian variation of 5-fluorouracil catabolism in isolated perfused rat liver

4 November 2022

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Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

4 November 2022

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Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA

4 November 2022

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Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells

4 November 2022

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Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice

4 November 2022

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Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma

4 November 2022

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Overview: rational basis for development of fluoropyrimidine/5-formyltetrahydrofolate combination chemotherapy

4 November 2022

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Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine

4 November 2022

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DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate

4 November 2022

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Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells

4 November 2022

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Identification of 5-fluorocytidine in RNA from Escherichia coli grown in the presence of 5-fluorouracil

4 November 2022

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The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

4 November 2022

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Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells

4 November 2022

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5-Fluorouracil and folinic acid: interesting biochemistry or effective treatment?

4 November 2022

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Enhancement of the antitumor activity of 5-fluorouracil by uridine rescue

4 November 2022

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Uracil DNa-glycosylase from HeLa cells: general properties, substrate specificity and effect of uracil analogs

4 November 2022

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Enhancement of 5-fluorouracil incorporation into human lymphoblast ribonucleic acid

4 November 2022

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Biologic effect of 5-fluoro-2′-deoxyuridine incorporation in L1210 deoxyribonucleic acid

4 November 2022

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The uptake of pteroyl(14-C)glutamic acid into rat liver and its incorporation into the natural pteroyl poly-gamma-glutamates of that organ

4 November 2022

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4 November 2022

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Turnover of Ribosomal RNA in Rat Liver

4 November 2022

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Interaction between 5-fluorouracil and DNA of human colon adenocarcinoma

4 November 2022

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The increased cytotoxicity in colon adenocarcinoma of methotrexate-5-fluorouracil is not associated with increased induction of lesions in DNA by 5-fluorouracil

4 November 2022

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5-Fluorouracil incorporation in DNA of human breast carcinoma cells

4 November 2022

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Enhancement of the antitumor effects of 5-fluorouracil by folinic acid

4 November 2022

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Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase

4 November 2022

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Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion

4 November 2022

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THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI

4 November 2022

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Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. II. Independent nucleotide pools for nucleic acid synthesis

4 November 2022

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Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts

4 November 2022

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Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft

4 November 2022

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On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

4 November 2022

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Incorporation of 5-fluorouracil into murine bone marrow DNA in vivo

4 November 2022

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The effect of 5-fluorouracil on DNA chain elongation in intact bone marrow cells.

4 November 2022

105

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Alteration of the secondary structure of newly synthesized DNA from murine bone marrow cells by 5-fluorouracil

4 November 2022

107

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Purification and properties of the human placental uracil DNA glycosylase

4 November 2022

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Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized

4 November 2022

109

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Splicing of messenger RNA precursors

4 November 2022

110

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Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation

4 November 2022

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Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation

4 November 2022

114

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Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA

4 November 2022

115

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Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation

4 November 2022

116

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Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation

4 November 2022

117

1 reference

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Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver

4 November 2022

118

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Precursor-dependent differences in the incorporation of fluorouracil in RNA

4 November 2022

119

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Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity

4 November 2022

120

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4 November 2022

5-Fluorouracil (FUra)

124

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Infrared and Ultraviolet Studies on the Tautomeric Equilibria in Aqueous Medium between Monoanionic Species of Uracil, Thymine, 5-Fluorouracil, and Other 2,4-Diketopyrimidines

4 November 2022

126

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The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives

4 November 2022

132

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4 November 2022

Identifiers

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15 August 2017

1 reference