(Q39342489)

11 September 2017

title

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation (English)

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11 September 2017

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31 May 2020

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31 May 2020

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31 May 2020

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31 May 2020

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31 May 2020

Marco Prinz

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31 May 2020

Peter Wieghofer

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31 May 2020

Yochai Wolf

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31 May 2020

Diana Varol

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31 May 2020

Stefanie M Brendecke

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31 May 2020

Katrin Kierdorf

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31 May 2020

Moumita Datta

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31 May 2020

Tom Luedde

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31 May 2020

Mathias Heikenwalder

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31 May 2020

language of work or name

English

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publication date

29 September 2013

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11 September 2017

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31 May 2020

volume

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31 May 2020

issue

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31 May 2020

page(s)

1618-1626

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Genetic approaches to study glial cells in the rodent brain.

31 May 2020

cites work

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12 December 2020

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Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

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Anergic CD8+ T lymphocytes have impaired NF-κB activation with defects in p65 phosphorylation and acetylation

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Nano-electrospray tandem mass spectrometric analysis of the acetylation state of histones H3 and H4 in stationary phase in Saccharomyces cerevisiae.

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Ubiquitin-mediated activation of TAK1 and IKK.

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12 December 2020

Microglia promote the death of developing Purkinje cells

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TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

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12 December 2020

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

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Microglial interactions with synapses are modulated by visual experience

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Microglial physiology: unique stimuli, specialized responses

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Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

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TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils

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TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

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Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells

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Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

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Targeting of TAK1 in inflammatory disorders and cancer

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12 December 2020

Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection

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12 December 2020

Essential function for the kinase TAK1 in innate and adaptive immune responses

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The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.

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12 December 2020

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

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12 December 2020

A lineage of myeloid cells independent of Myb and hematopoietic stem cells

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12 December 2020

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

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12 December 2020

Murine microglial cells produce and respond to interleukin-18.

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12 December 2020

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.

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12 December 2020

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

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12 December 2020

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

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12 December 2020

RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways

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12 December 2020

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12 December 2020

The myeloid cells of the central nervous system parenchyma

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Cell Type-Specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia after Excitotoxic Injury

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IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system

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12 December 2020

Blood monocytes consist of two principal subsets with distinct migratory properties

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12 December 2020

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

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12 December 2020

Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production

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12 December 2020

Control of microglial neurotoxicity by the fractalkine receptor

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In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens

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Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy

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Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases

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12 December 2020

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

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12 December 2020

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

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12 December 2020

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

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12 December 2020

Tissue-specific targeting of cytokine unresponsiveness in transgenic mice

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12 December 2020

Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation

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12 December 2020

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

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12 December 2020