(Q38075370)

28 August 2017

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title

IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer (English)

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28 August 2017

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28 August 2017

Kelly Verhelst

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28 August 2017

Lynn Verstrepen

series ordinal

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28 August 2017

Isabelle Carpentier

series ordinal

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28 August 2017

language of work or name

English

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publication date

17 January 2013

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28 August 2017

published in

Biochemical Pharmacology

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28 August 2017

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28 August 2017

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28 August 2017

page(s)

873-880

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TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

28 August 2017

cites work

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12 December 2020

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε

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12 December 2020

Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.

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12 December 2020

Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.

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12 December 2020

Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

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12 December 2020

NAK is an IkappaB kinase-activating kinase

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12 December 2020

Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells

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12 December 2020

NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.

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12 December 2020

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

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12 December 2020

Pathogen recognition by the innate immune system

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12 December 2020

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12 December 2020

Signaling to NF-kappaB by Toll-like receptors

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12 December 2020

Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.

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12 December 2020

IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli

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12 December 2020

IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer

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12 December 2020

Emerging role of ubiquitination in antiviral RIG-I signaling

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12 December 2020

IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation

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12 December 2020

IKKepsilon: a bridge between obesity and inflammation

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12 December 2020

Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

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12 December 2020

Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.

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12 December 2020

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

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12 December 2020

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

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12 December 2020

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

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12 December 2020

SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death

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12 December 2020

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

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12 December 2020

Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer

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12 December 2020

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice

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12 December 2020

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

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12 December 2020

The Stat family of transcription factors have diverse roles in mammary gland development

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12 December 2020

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance

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12 December 2020

Emerging roles for the non-canonical IKKs in cancer

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12 December 2020

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance

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12 December 2020

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

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12 December 2020

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

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12 December 2020

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

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12 December 2020

Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases

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12 December 2020

Regulation of IKKε Expression by Akt2 Isoform

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12 December 2020

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

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12 December 2020

Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production

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12 December 2020

The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

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12 December 2020

Over-expression of IkappaB-kinase-epsilon (IKKepsilon/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines

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12 December 2020

Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice

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12 December 2020

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

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12 December 2020

Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions

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12 December 2020

Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1.

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12 December 2020

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilo

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12 December 2020

IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation

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12 December 2020

NFkappaB-dependent chemoresistance in solid tumors.

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12 December 2020

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

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12 December 2020

Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1

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12 December 2020

Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta

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12 December 2020

Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.

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12 December 2020

Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection

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12 December 2020

The protein kinase IKKepsilon regulates energy balance in obese mice

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12 December 2020

DUBA: a deubiquitinase that regulates type I interferon production

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12 December 2020

Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation

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12 December 2020

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

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12 December 2020

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

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12 December 2020

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

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12 December 2020

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

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12 December 2020

Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis

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12 December 2020

IKBKE is over‐expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF‐κB

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12 December 2020

Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin

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12 December 2020

Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants

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12 December 2020

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

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12 December 2020

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia

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12 December 2020

Kinome expression profiling identifies IKBKE as a predictor of overall survival in clear cell renal cell carcinoma patients

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12 December 2020

IKKε modulates RSV-induced NF-κB-dependent gene transcription

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12 December 2020

IKK-ε coordinates invasion and metastasis of ovarian cancer.

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12 December 2020

IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer

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12 December 2020

Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon

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12 December 2020

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling

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12 December 2020

Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers

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12 December 2020

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

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12 December 2020

Interferon beta for rheumatoid arthritis: new clothes for an old kid on the block.

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12 December 2020

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

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12 December 2020

Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon

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12 December 2020

Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases

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12 December 2020

Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin.

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12 December 2020

Novel cross-talk within the IKK family controls innate immunity

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12 December 2020

Obesity, Inflammation, and Insulin Resistance

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12 December 2020

IκB-Kinase-ε (IKKε/IKKi/IκBKε) expression and localization in prostate cancer tissues

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12 December 2020

Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells

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12 December 2020

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

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12 December 2020

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint

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12 December 2020

Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.

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12 December 2020

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

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12 December 2020

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

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12 December 2020

Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i

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12 December 2020

TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

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12 December 2020

NF-κB: where did it come from and why?

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12 December 2020

10.1016/J.BCP.2013.01.007

Identifiers

DOI

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28 August 2017

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