(Q37924177)

25 August 2017

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title

MicroRNA replacement therapy for cancer (English)

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25 August 2017

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Thomas D Schmittgen

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25 August 2017

Jon C Henry

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25 August 2017

Ana Clara P Azevedo-Pouly

series ordinal

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25 August 2017

publication date

31 August 2011

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25 August 2017

published in

Pharmaceutical Research

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

3030-3042

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MicroRNAs: genomics, biogenesis, mechanism, and function

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Targeting microRNAs in cancer: rationale, strategies and challenges

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA control of muscle development and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA dysregulation in psychiatric disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Diabetes mellitus, a microRNA-related disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA signatures in human cancers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNAs: novel biomarkers for human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Small molecule modifiers of the microRNA and RNA interference pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

21 January 2018

Genomics of microRNA.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Slicer and the argonautes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA expression profiles classify human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA gene expression deregulation in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

A high-throughput method to monitor the expression of microRNA precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

A microRNA expression signature of human solid tumors defines cancer gene targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Expression profiling identifies microRNA signature in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Impaired microRNA processing enhances cellular transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

A microRNA polycistron as a potential human oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA expression in zebrafish embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Chemical modification of siRNAs for in vivo use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Tolerance for mutations and chemical modifications in a siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

siRNA function in RNAi: a chemical modification analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Chemical modification of siRNAs to improve serum stability without loss of efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

In vivo activity of nuclease-resistant siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Modifications in small interfering RNA that separate immunostimulation from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

RAS is regulated by the let-7 microRNA family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Transcriptional regulation and transformation by Myc proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

let-7 microRNA functions as a potential growth suppressor in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA 29b functions in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-34a repression of SIRT1 regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Identification of novel genes coding for small expressed RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Downregulation of miR-122 in the rodent and human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-143 and -145 in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Putative tumor suppressor miR‐145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-145 targets YES and STAT1 in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-143 regulates adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA miR-199a* regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Regulation of the hepatitis C virus genome replication by miR-199a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

microRNA-203 suppresses bladder cancer development by repressing bcl-w expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Micro-RNA profiling in kidney and bladder cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Aberrant expression of miR-203 and its clinical significance in gastric and colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MiRNA-451 plays a role as tumor suppressor in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Novel RNA-based strategies for therapeutic gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

p53 represses c-Myc through induction of the tumor suppressor miR-145

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

The let-7 microRNA reduces tumor growth in mouse models of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Regression of murine lung tumors by the let-7 microRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miR-126 functions as a tumour suppressor in human gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Cancer therapy via modulation of micro RNA levels: a promising future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

Lin28 promotes transformation and is associated with advanced human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0548-9

MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion

21 January 2018

1 reference

12 December 2020

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation

1 reference

12 December 2020

Synthetic microRNA and double-stranded RNA targeting the 3'-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells

1 reference

12 December 2020

Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma

1 reference

12 December 2020

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.

1 reference

12 December 2020

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma

1 reference

12 December 2020

MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma

1 reference

12 December 2020

MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers.

1 reference

12 December 2020

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

1 reference

12 December 2020

miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein

1 reference

12 December 2020

Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.

1 reference

12 December 2020

Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer

1 reference

12 December 2020

10.1007/S11095-011-0548-9

Identifiers

DOI

1 reference

25 August 2017

1 reference