(Q37903659)

25 August 2017

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title

From unwinding to clamping - the DEAD box RNA helicase family (English)

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25 August 2017

Eckhard Jankowsky

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Patrick Linder

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25 August 2017

publication date

22 July 2011

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Nature Reviews Molecular Cell Biology

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

505-516

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RNA helicases at work: binding and rearranging

25 August 2017

cites work

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Helicases: amino acid sequence comparisons and structure-function relationships

31 March 2020

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SF1 and SF2 helicases: family matters

31 March 2020

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Structure and mechanism of helicases and nucleic acid translocases

31 March 2020

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The DEAD-box protein family of RNA helicases

31 March 2020

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DEAD‐box proteins as RNA helicases and chaperones

31 March 2020

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Helicase structure and mechanism

31 March 2020

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31 March 2020

Birth of the D-E-A-D box

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Dead-box proteins: a family affair--active and passive players in RNP-remodeling

31 March 2020

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The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

31 March 2020

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Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop

31 March 2020

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Structure of the Yeast DEAD Box Protein Mss116p Reveals Two Wedges that Crimp RNA

31 March 2020

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Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa

31 March 2020

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Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

31 March 2020

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The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

31 March 2020

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The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner

31 March 2020

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Solution and crystal structures of mRNA exporter Dbp5p and its interaction with nucleotides

31 March 2020

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Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1.

31 March 2020

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Structure of the RNA Binding Domain of a DEAD-Box Helicase Bound to Its Ribosomal RNA Target Reveals a Novel Mode of Recognition by an RNA Recognition Motif

31 March 2020

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A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility

31 March 2020

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The Thermus thermophilus DEAD box helicase Hera contains a modified RNA recognition motif domain loosely connected to the helicase core

31 March 2020

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A structural model for the DEAD box helicase YxiN in solution: localization of the RNA binding domain.

31 March 2020

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DExD/H box RNA helicases: from generic motors to specific dissociation functions

31 March 2020

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RNA helicases--one fold for many functions

31 March 2020

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Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A

31 March 2020

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Further characterization of the helicase activity of eIF4A. Substrate specificity

31 March 2020

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The DEAD-box protein Ded1 unwinds RNA duplexes by a mode distinct from translocating helicases

31 March 2020

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Studies on three E. coli DEAD-box helicases point to an unwinding mechanism different from that of model DNA helicases

31 March 2020

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Translocation and unwinding mechanisms of RNA and DNA helicases

31 March 2020

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Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone

31 March 2020

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DEAD-box proteins unwind duplexes by local strand separation

31 March 2020

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Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor

31 March 2020

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An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

31 March 2020

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Identification of novel guide RNAs from the mitochondria of Trypanosoma brucei

31 March 2020

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Function and synthesis of small nucleolar RNAs

31 March 2020

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DEAD-box proteins can completely separate an RNA duplex using a single ATP.

31 March 2020

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Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA.

31 March 2020

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The DEAD box helicase YxiN maintains a closed conformation during ATP hydrolysis

31 March 2020

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ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding

31 March 2020

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The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA

31 March 2020

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Mechanism of ATP turnover inhibition in the EJC

31 March 2020

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Unwinding by local strand separation is critical for the function of DEAD-box proteins as RNA chaperones

31 March 2020

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Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase

31 March 2020

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Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase

31 March 2020

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The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.

31 March 2020

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Protein displacement by DExH/D "RNA helicases" without duplex unwinding

31 March 2020

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Discriminatory RNP remodeling by the DEAD-box protein DED1.

31 March 2020

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The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling events

31 March 2020

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Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases

31 March 2020

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Active disruption of an RNA-protein interaction by a DExH/D RNA helicase

31 March 2020

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Rearrangement of structured RNA via branch migration structures catalysed by the highly related DEAD-box proteins p68 and p72.

31 March 2020

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RNA structural rearrangement via unwinding and annealing by the cyanobacterial RNA helicase, CrhR

31 March 2020

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ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1.

31 March 2020

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Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity

31 March 2020

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Ddx42p--a human DEAD box protein with RNA chaperone activities

31 March 2020

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Structural domains involved in the RNA folding activity of RNA helicase II/Gu protein

31 March 2020

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DEAD-box-protein-assisted RNA structure conversion towards and against thermodynamic equilibrium values

31 March 2020

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Kinetic redistribution of native and misfolded RNAs by a DEAD-box chaperone

31 March 2020

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The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

31 March 2020

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

31 March 2020

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Structural insights into the exon junction complex

31 March 2020

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EJCs at the heart of translational control

31 March 2020

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

31 March 2020

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An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

31 March 2020

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A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

31 March 2020

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The exon junction complex differentially marks spliced junctions

31 March 2020

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Disassembly of exon junction complexes by PYM

31 March 2020

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MLN51 stimulates the RNA-helicase activity of eIF4AIII.

31 March 2020

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Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay

31 March 2020

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A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes

31 March 2020

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An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components

31 March 2020

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The mRNA export factor Dbp5 is associated with Balbiani ring mRNP from gene to cytoplasm

31 March 2020

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mRNA helicases: the tacticians of translational control

31 March 2020

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eIF4A: the godfather of the DEAD box helicases

31 March 2020

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Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII

31 March 2020

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Yeast RNA helicases of the DEAD-box family involved in translation initiation

31 March 2020

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Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function

31 March 2020

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

31 March 2020

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Interactions between eIF4AI and its accessory factors eIF4B and eIF4H

31 March 2020

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Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

31 March 2020

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Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H

31 March 2020

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Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

31 March 2020

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Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

31 March 2020

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Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions

31 March 2020

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Structural basis for the enhancement of eIF4A helicase activity by eIF4G.

31 March 2020

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eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism

31 March 2020

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Synergistic activation of eIF4A by eIF4B and eIF4G.

31 March 2020

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The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

31 March 2020

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The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection

31 March 2020

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Dynamics and processivity of 40S ribosome scanning on mRNA in yeast

31 March 2020

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Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.

31 March 2020

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Eukaryotic translation initiation factors and regulators

31 March 2020

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Molecular mechanisms of translational control

31 March 2020

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eIF4E, the mRNA cap-binding protein: from basic discovery to translational research

31 March 2020

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The cap-dependent translation apparatus integrates and amplifies cancer pathways

31 March 2020

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The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

31 March 2020

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Structural basis for translational inhibition by the tumour suppressor Pdcd4

31 March 2020

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PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

31 March 2020

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Selective pharmacological targeting of a DEAD box RNA helicase.

31 March 2020

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RNA-Mediated Sequestration of the RNA Helicase eIF4A by Pateamine A Inhibits Translation Initiation

31 March 2020

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Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

31 March 2020

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Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII

31 March 2020

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Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism

31 March 2020

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Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export

31 March 2020

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Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

31 March 2020

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The mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translation

31 March 2020

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The DEAD-box RNA helicase Dbp5 functions in translation termination

31 March 2020

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Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export

31 March 2020

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Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export

31 March 2020

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Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

31 March 2020

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Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells

31 March 2020

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The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore

31 March 2020

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The DEXD/H-box RNA Helicase DDX19 Is Regulated by an -Helical Switch

31 March 2020

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The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p

31 March 2020

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A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

31 March 2020

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Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases

31 March 2020

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The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1

31 March 2020

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The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1

31 March 2020

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Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B

31 March 2020

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Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

31 March 2020

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A DEAD-box protein functions as an ATP-dependent RNA chaperone in group I intron splicing

31 March 2020

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A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone

31 March 2020

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Protein-facilitated folding of group II intron ribozymes

31 March 2020

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Single-molecule analysis of Mss116-mediated group II intron folding.

31 March 2020

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Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome

31 March 2020

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The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae

31 March 2020

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DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

31 March 2020

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An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

31 March 2020

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A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA

31 March 2020

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Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha

31 March 2020

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The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

31 March 2020

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Escherichia coli DbpA is an RNA helicase that requires hairpin 92 of 23S rRNA.

31 March 2020

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Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis

31 March 2020

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Phosphorylation of threonine 204 of DEAD-box RNA helicase DDX3 by cyclin B/cdc2 in vitro.

31 March 2020

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Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase

31 March 2020

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Evidence for two mechanisms for DNA unwinding catalyzed by DNA helicases

31 March 2020

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12 December 2020

An ancient anion-binding structural module in RNA and DNA helicases

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12 December 2020

Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis

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12 December 2020

Do human RNA helicases have a role in cancer?

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12 December 2020

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors

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12 December 2020

Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation

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12 December 2020

Identifiers

DOI

10.1038/NRM3154

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Dimensions Publication ID

25 August 2017

1052580278

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