(Q40340775)

19 September 2017

title

Thymidylate synthetase - substrate complex formation (English)

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19 September 2017

P V Danenberg

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19 September 2017

A Lockshin

series ordinal

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19 September 2017

publication date

1 March 1982

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Molecular and Cellular Biochemistry

19 September 2017

published in

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19 September 2017

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19 September 2017

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19 September 2017

page(s)

49-57

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Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography

19 September 2017

cites work

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12 December 2020

Nalpha-(pteroyltetra (gamma-glutamyl))-lysine as a ligand for the purification of thymidylate synthetase by affinity chromatography

1 reference

12 December 2020

THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES

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12 December 2020

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis

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12 December 2020

Essential arginyl residues in thymidylate synthetase

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12 December 2020

Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate

1 reference

12 December 2020

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

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12 December 2020

The purification and properties of thymidylate synthetase from chick embryo extracts

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12 December 2020

Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase

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12 December 2020

Interaction of deoxyuridylate with thymidylate synthetase

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12 December 2020

Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.

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12 December 2020

Studies on the reactivity of the essential cysteine of thymidylate synthetase

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12 December 2020

31P NMR studies on the interaction of deoxyuridylate with thymidylate synthase

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12 December 2020

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

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12 December 2020

Inhibition of thymidylate synthetase by some analogs of tetrahydrofolic acid

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12 December 2020

19F nuclear magnetic resonance investigation of the ternary complex formed between native thymidylate synthetase, 5-fluoro-2'-deoxyuridylate, and 5,10-methylenetetrahydrofolate

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12 December 2020

Addition of sodium bisulfite to uracil and to cytosine

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12 December 2020

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1 reference

12 December 2020

The use of competitive inhibitors in studying the mechanism of action of some enzyme systems utilizing three substrates

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12 December 2020

Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

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12 December 2020

Purification of mouse liver thymidylate synthetase by affinity chromatography using 10-methyl-5,8-dideazafolate as the affinant

1 reference

12 December 2020

The primary structure of Lactobacillus casei thymidylate synthetase. III. The use of 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine and limited tryptic peptides to establish the complete amino acid sequence of the enzyme

1 reference

12 December 2020

Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymus

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12 December 2020

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

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12 December 2020

Evidence for a sequential interaction of the subunits of thymidylate synthetase

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12 December 2020

Model studies of thymidylate synthetase. Neighboring-group facilitation of electrophilic substitution reactions of uracil furanosides

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12 December 2020

A calorimetric study of the binding of 2′-deoxyuridine-5′-phosphate and 5-fluoro-2′-deoxyuridine-5′-phosphate to thymidylate synthetase

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12 December 2020

Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.

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12 December 2020

The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4

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12 December 2020

A kinetic study of thymidylate synthase from Lactobacillus casei

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12 December 2020

Amino acid sequence at the FdUMP binding site of thymidylate synthetase

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12 December 2020

5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates

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12 December 2020

Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate

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12 December 2020

The Statistical Analysis of Enzyme Kinetic Data

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12 December 2020

Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation

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12 December 2020

Thymidylate synthetase - a target enzyme in cancer chemotherapy

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12 December 2020

Use of chromium-adenosine triphosphate and lyxose to elucidate the kinetic mechanism and coordination state of the nucleotide substrate for yeast hexokinase

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12 December 2020

Tight-binding inhibitors-I. Kinetic behavior

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12 December 2020

Flip-flop mechanisms in enzymology. A model: the alkaline phosphatase of Escherichia coli

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12 December 2020

Thymidylate synthetase purified to homogeneity from human leukemic cells

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12 December 2020

Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization

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12 December 2020

Thymidylate synthetase catalyzed exchange of tritium from [5-3H]-2'-deoxyuridylate for protons of water

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12 December 2020

Measurement of protein-binding phenomena by gel filtration

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12 December 2020

Fluorine-19 nuclear magnetic resonance characterization of ternary complexes of folate derivatives, 5-fluorodeoxyuridylate and Lactobacillus

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12 December 2020

Identifiers

DOI

10.1007/BF00229539

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19 September 2017

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