(Q36658038)

English

Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection

scientific article published on 7 March 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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chronic lymphocytic leukemia

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inferred from title

William G Wierda

6

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William G Wierda

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Europe PubMed Central

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15 August 2017

Michael J. Keating

5

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Michael J Keating

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Europe PubMed Central

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15 August 2017

10

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John C Byrd

1 reference

Europe PubMed Central

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15 August 2017

11

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Neil E Kay

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Europe PubMed Central

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15 August 2017

Laura Z Rassenti

4

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Laura Z Rassenti

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Europe PubMed Central

PMC publication ID

15 August 2017

7

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John G Gribben

1 reference

Europe PubMed Central

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15 August 2017

9

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Kanti R Rai

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Europe PubMed Central

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15 August 2017

George F Widhopf

3

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George F Widhopf

1 reference

Europe PubMed Central

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15 August 2017

Emanuela M Ghia

1

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Emanuela M Ghia

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Sonia Jain

2

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Europe PubMed Central

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15 August 2017

Jennifer R Brown

8

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Europe PubMed Central

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15 August 2017

Andrew W Greaves

12

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Europe PubMed Central

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15 August 2017

Thomas J Kipps

13

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15 August 2017

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publication date

7 March 2008

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Europe PubMed Central

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15 August 2017

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Europe PubMed Central

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15 August 2017

111

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Europe PubMed Central

PMC publication ID

15 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

5101-5108

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.

1 reference

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30 September 2017

Receptor editing in lymphocyte development and central tolerance.

1 reference

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30 September 2017

Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies.

1 reference

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30 September 2017

IMGT, the international ImMunoGeneTics information system

1 reference

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30 September 2017

The scope of receptor editing and its association with autoimmunity

1 reference

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30 September 2017

IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

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Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern

1 reference

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30 September 2017

Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Autoreactive B cells in the marginal zone that express dual receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

The inference of antigen selection on Ig genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

B-cell antigen receptor competence regulates B-lymphocyte selection and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Lack of allelic exclusion in B cell chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

30 September 2017

IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

28 June 2018

Receptor revision of immunoglobulin heavy chain genes in human MALT lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

28 June 2018

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

28 June 2018

Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

28 June 2018

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

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Rare detection of phenotypically immature lymphocytes in Hashimoto thyroiditis and rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

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Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

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Regulation of anti-phosphatidylserine antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Do B-cell chronic lymphocytic leukemia patients with Ig VH3-21 genes constitute a new subset of chronic lymphocytic leukemia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Editors and editing of anti-DNA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

20 September 2018

Receptor editing and commitment in B lymphocytes

1 reference

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20 September 2018

ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

4 December 2018

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

1 reference

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4 December 2018

Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2384137

4 December 2018

A negative regulatory role for Ig-alpha during B cell development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

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Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18326815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2007-12-130229

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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