(Q36491858)

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Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.

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Europe PubMed Central

PMC publication ID

14 August 2017

Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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chronic lymphocytic leukemia

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William G Wierda

5

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William G Wierda

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Europe PubMed Central

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14 August 2017

Michael J. Keating

7

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Michael J Keating

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Europe PubMed Central

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14 August 2017

6

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John C Byrd

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Europe PubMed Central

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14 August 2017

Laura Z Rassenti

4

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Laura Z Rassenti

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Europe PubMed Central

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14 August 2017

8

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John G Gribben

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Europe PubMed Central

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14 August 2017

9

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Kanti R Rai

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Europe PubMed Central

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14 August 2017

George F Widhopf

1

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George F Widhopf

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Europe PubMed Central

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14 August 2017

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Craig J Goldberg

2

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Europe PubMed Central

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14 August 2017

Traci L Toy

3

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Europe PubMed Central

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14 August 2017

Thomas J Kipps

10

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14 August 2017

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publication date

3 August 2007

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Europe PubMed Central

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14 August 2017

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Europe PubMed Central

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14 August 2017

111

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Europe PubMed Central

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14 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

3137-3144

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

IMGT, the international ImMunoGeneTics information system

1 reference

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

1 reference

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30 September 2017

IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265453

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Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia

1 reference

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Chronic lymphocytic leukemia: revelations from the B-cell receptor.

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Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

1 reference

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B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

1 reference

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Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia

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A model B-cell superantigen and the immunobiology of B lymphocytes

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

1 reference

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Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire

1 reference

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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

1 reference

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1 reference

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The creation of diversity in the human immunoglobulin V(lambda) repertoire

1 reference

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Lack of allelic exclusion in B cell chronic lymphocytic leukemia

1 reference

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Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells

1 reference

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Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain

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A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles

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Anti-B cell autoantibodies encoded by VH 4-21 genes in human fetal spleen do not require in vivo somatic selection

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1 reference

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Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA.

1 reference

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Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity

1 reference

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Isolation and characterization of a light chain variable region gene for human rheumatoid factors

1 reference

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Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265453

30 September 2017

Evidence for somatic selection of natural autoantibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265453

30 September 2017

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1 reference

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The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR); frequent occurrence of features often assigned to autoimmunity

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Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features

1 reference

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Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia

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Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.

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Immunoglobulin light chain repertoire in chronic lymphocytic leukemia.

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

1 reference

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Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia

1 reference

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Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

1 reference

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Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells

1 reference

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Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire

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Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations

1 reference

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inferred from PubMed ID database lookup

Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies

1 reference

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based on heuristic

inferred from PubMed ID database lookup

A human anti-cardiolipin autoantibody is encoded by developementally restricted heavy and light chain variable region genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17675554

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inferred from PubMed ID database lookup

Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Pairing of variable heavy and variable kappa chains in individual naive and memory B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17675554

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based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms and selection influence the generation of the human V lambda J lambda repertoire

1 reference

https://pubmed.ncbi.nlm.nih.gov/17675554

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1182/BLOOD-2007-02-073130

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Europe PubMed Central

PMC publication ID

14 August 2017

release_gbuvgai5j5bgzhhfamzydg33ze

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24 November 2022

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PMC publication ID

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Europe PubMed Central

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14 August 2017

PubMed publication ID

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Europe PubMed Central

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14 August 2017

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