(Q36504877)

14 August 2017

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title

Alternative splicing and RNA selection pressure--evolutionary consequences for eukaryotic genomes (English)

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alternative mRNA splicing, via spliceosome

14 August 2017

main subject

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Yi Xing

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14 August 2017

Christopher Lee

series ordinal

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14 August 2017

publication date

13 June 2006

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14 August 2017

published in

Nature Reviews Genetics

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

499-509

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An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

14 August 2017

cites work

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21 January 2018

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A genomic view of alternative splicing

21 January 2018

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Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform

21 January 2018

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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

21 January 2018

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Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles

21 January 2018

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Selecting for functional alternative splices in ESTs

21 January 2018

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Computational comparative analyses of alternative splicing regulation using full-length cDNA of various eukaryotes

21 January 2018

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Low conservation of alternative splicing patterns in the human and mouse genomes.

21 January 2018

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Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss

21 January 2018

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Conservation of human alternative splice events in mouse

21 January 2018

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Species-specific variation of alternative splicing and transcriptional initiation in six eukaryotes.

21 January 2018

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Alternative pre-mRNA splicing: the logic of combinatorial control

21 January 2018

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Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity

21 January 2018

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The Sequence of the Human Genome

21 January 2018

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Alternative splicing: increasing diversity in the proteomic world

21 January 2018

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YIDB: the Yeast Intron DataBase.

21 January 2018

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Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast

21 January 2018

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Alternative splicing and genome complexity

21 January 2018

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The origin of new genes: glimpses from the young and old

21 January 2018

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Duplication and divergence: the evolution of new genes and old ideas

21 January 2018

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Changes in Alternative Splicing of Human and Mouse Genes Are Accompanied by Faster Evolution of Constitutive Exons

21 January 2018

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The evolving roles of alternative splicing

21 January 2018

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Alternative splicing and evolution

21 January 2018

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How did alternative splicing evolve?

21 January 2018

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Alu sequences in the coding regions of mRNA: a source of protein variability

21 January 2018

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Transposable elements are found in a large number of human protein-coding genes

21 January 2018

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Alu-containing exons are alternatively spliced

21 January 2018

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The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons

21 January 2018

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From "junk" to gene: curriculum vitae of a primate receptor isoform gene

21 January 2018

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Alu-SINE exonization: en route to protein-coding function

21 January 2018

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Do transposable elements really contribute to proteomes?

21 January 2018

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An unappreciated role for RNA surveillance

21 January 2018

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Common exon duplication in animals and its role in alternative splicing

21 January 2018

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Origin of alternative splicing by tandem exon duplication

21 January 2018

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Evolutionary convergence of alternative splicing in ion channels

21 January 2018

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Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.

21 January 2018

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Origin and evolution of new exons in rodents

21 January 2018

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Evolution of alternative splicing: deletions, insertions and origin of functional parts of proteins from intron sequences

21 January 2018

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Evolution of the exon-intron structure and alternative splicing of the MAGE-A family of cancer/testis antigens.

21 January 2018

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The complexity of alternative splicing of hagoromo mRNAs is increased in an explosively speciated lineage in East African cichlids

21 January 2018

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Messenger RNA surveillance and the evolutionary proliferation of introns

21 January 2018

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

21 January 2018

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Cryptic genetic variation is enriched for potential adaptations

21 January 2018

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Negative selection pressure against premature protein truncation is reduced by alternative splicing and diploidy.

21 January 2018

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Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

21 January 2018

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Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

21 January 2018

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Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression

21 January 2018

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Evolution of alternative splicing after gene duplication

21 January 2018

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The Ka/Ks ratio: diagnosing the form of sequence evolution

21 January 2018

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Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models

21 January 2018

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Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates

21 January 2018

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Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences

21 January 2018

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A test of translational selection at 'silent' sites in the human genome: base composition comparisons in alternatively spliced genes.

21 January 2018

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Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing

21 January 2018

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The K(A)/K(S) ratio test for assessing the protein-coding potential of genomic regions: an empirical and simulation study

21 January 2018

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Assessing the application of Ka/Ks ratio test to alternatively spliced exons

21 January 2018

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Recognition of unknown conserved alternatively spliced exons

21 January 2018

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Can RNA selection pressure distort the measurement of Ka/Ks?

21 January 2018

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Adjusting for selection on synonymous sites in estimates of evolutionary distance

21 January 2018

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Mammalian housekeeping genes evolve more slowly than tissue-specific genes

21 January 2018

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Hearing silence: non-neutral evolution at synonymous sites in mammals

21 January 2018

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Ultraconserved Elements in the Human Genome

21 January 2018

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Intronic sequences flanking alternatively spliced exons are conserved between human and mouse

21 January 2018

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In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons

21 January 2018

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Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse

21 January 2018

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Unusual intron conservation near tissue-regulated exons found by splicing microarrays

21 January 2018

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A non-EST-based method for exon-skipping prediction

21 January 2018

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A computational and experimental approach toward a priori identification of alternatively spliced exons

21 January 2018

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Identification and analysis of alternative splicing events conserved in human and mouse

21 January 2018

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Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines

21 January 2018

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

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Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis

21 January 2018

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Emerging roles of BRCA1 alternative splicing

21 January 2018

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Structure and evolution of the alternatively spliced fast troponin T isoform gene

21 January 2018

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Protein modularity of alternatively spliced exons is associated with tissue-specific regulation of alternative splicing

21 January 2018

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Evidence for a subpopulation of conserved alternative splicing events under selection pressure for protein reading frame preservation

21 January 2018

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A combinatorial code for splicing silencing: UAGG and GGGG motifs

21 January 2018

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Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression

21 January 2018

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Genomic variants in exons and introns: identifying the splicing spoilers

21 January 2018

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The origin and evolution of model organisms

21 January 2018

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How prevalent is functional alternative splicing in the human genome?

21 January 2018

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Predictive identification of exonic splicing enhancers in human genes

21 January 2018

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Systematic identification and analysis of exonic splicing silencers.

21 January 2018

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Computational searches for splicing signals.

21 January 2018

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Computational definition of sequence motifs governing constitutive exon splicing.

21 January 2018

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Single nucleotide polymorphism-based validation of exonic splicing enhancers

21 January 2018

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Synonymous SNPs provide evidence for selective constraint on human exonic splicing enhancers

21 January 2018

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Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?

21 January 2018

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Cisrequirements for alternative splicing of the cardiac troponin T pre–mRNA

21 January 2018

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A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements

21 January 2018

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A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing

21 January 2018

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Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures

21 January 2018

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The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA.

21 January 2018

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Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5' splice site and an adjacent intronic stem-loop cis element

21 January 2018

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Influence of RNA secondary structure on the pre-mRNA splicing process

21 January 2018

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Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals

21 January 2018

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Evidence for the regulation of alternative splicing via complementary DNA sequence repeats

21 January 2018

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Statistical evidence for conserved, local secondary structure in the coding regions of eukaryotic mRNAs and pre-mRNAs

21 January 2018

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Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution.

21 January 2018

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Listening to silence and understanding nonsense: exonic mutations that affect splicing

21 January 2018

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The role of common single-nucleotide polymorphisms on exon 9 and exon 12 skipping in nonmutated CFTR alleles

21 January 2018

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Are splicing mutations the most frequent cause of hereditary disease?

21 January 2018

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A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents

21 January 2018

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Nonclassical splicing mutations in the coding and noncoding regions of the ATM Gene: maximum entropy estimates of splice junction strengths

21 January 2018

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Linking C5 deficiency to an exonic splicing enhancer mutation

21 January 2018

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A mutation hotspot at the p14ARF splice site.

21 January 2018

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Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene

21 January 2018

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The SR protein SC35 is responsible for aberrant splicing of the E1alpha pyruvate dehydrogenase mRNA in a case of mental retardation with lactic acidosis

21 January 2018

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Mild Pelizaeus-Merzbacher disease caused by a point mutation affecting correct splicing of PLP1 mRNA.

21 January 2018

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Tyrosinaemia type I--de novo mutation in liver tissue suppressing an inborn splicing defect

21 January 2018

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Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation

21 January 2018

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

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Missense, nonsense, and neutral mutations define juxtaposed regulatory elements of splicing in cystic fibrosis transmembrane regulator exon 9.

21 January 2018

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Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

21 January 2018

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Regions of extreme synonymous codon selection in mammalian genes

21 January 2018

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Fast rate of evolution in alternatively spliced coding regions of mammalian genes.

21 January 2018

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Duplication, degeneration and subfunctionalization of the nested synapsin–Timp genes in Fugu

21 January 2018

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

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Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers

21 January 2018

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Lessons from mutant globins

21 January 2018

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Alternative splicing of conserved exons is frequently species-specific in human and mouse

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

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Estimating rates of alternative splicing in mammals and invertebrates

31 March 2020

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Alternative splicing and gene duplication are inversely correlated evolutionary mechanisms

31 March 2020

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Evidence for purifying selection acting on silent sites in BRCA1

31 March 2020

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Purifying selection on silent sites -- a constraint from splicing regulation?

31 March 2020

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The evolution of an alternatively spliced exon in the alphaA-crystallin gene

31 March 2020

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beta-Tropomyosin pre-mRNA folding around a muscle-specific exon interferes with several steps of spliceosome assembly

31 March 2020

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A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors

31 March 2020

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Identification of novel type VII collagen gene mutations resulting in severe recessive dystrophic epidermolysis bullosa

31 March 2020

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APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1896

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Dimensions Publication ID

14 August 2017

1023159960

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