(Q36362397)

13 August 2017

1 reference

title

From acute ER stress to physiological roles of the Unfolded Protein Response (English)

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13 August 2017

Wu J

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13 August 2017

Kaufman RJ

series ordinal

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13 August 2017

publication date

1 March 2006

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Cell Death & Differentiation

13 August 2017

published in

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

374-384

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Protein folding in the ER.

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A trip to the ER: coping with stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Peptide-binding specificity of the molecular chaperone BiP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Stress-induced gene expression requires programmed recovery from translational repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Biogenesis of the endoplasmic reticulum in activated B lymphocytes: temporal relationships between the induction of protein N-glycosylation activity and the biosynthesis of membrane protein and phospholipid.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Immunoglobulin heavy chain binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Activation of an unfolded protein response during differentiation of antibody-secreting B cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A role for the unfolded protein response in optimizing antibody secretion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Mitochondrial dysfunction and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Nitric oxide and vascular responses in Type I diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A central role for JNK in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Coordinated action of protein tyrosine phosphatases in insulin signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ATF6 modulates SREBP2-mediated lipogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Procollagen folding and assembly: the role of endoplasmic reticulum enzymes and molecular chaperones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Luman is capable of binding and activating transcription from the unfolded protein response element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401840

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401840

1 reference

Dimensions Publication ID

13 August 2017

1042133287

0 references

1 reference