(Q36140085)

12 August 2017

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title

Notch signaling in the mammalian central nervous system: insights from mouse mutants (English)

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12 August 2017

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Keejung Yoon

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12 August 2017

Nicholas Gaiano

series ordinal

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12 August 2017

language of work or name

English

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publication date

1 June 2005

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12 August 2017

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

709-715

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Notch signaling: cell fate control and signal integration in development

12 August 2017

cites work

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7 January 2021

The role of notch in promoting glial and neural stem cell fates

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7 January 2021

Notch1 is essential for postimplantation development in mice.

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7 January 2021

Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation

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7 January 2021

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors

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7 January 2021

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

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7 January 2021

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

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7 January 2021

Maintenance of somite borders in mice requires the Delta homologue DII1.

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7 January 2021

Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes

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7 January 2021

Dosage-sensitive requirement for mouse Dll4 in artery development

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7 January 2021

Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

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7 January 2021

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

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7 January 2021

Serrate2 is disrupted in the mouse limb-development mutant syndactylism

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7 January 2021

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

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7 January 2021

Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process

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7 January 2021

Mouse numb is an essential gene involved in cortical neurogenesis

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7 January 2021

Multiple roles of mouse Numb in tuning developmental cell fates.

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7 January 2021

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

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7 January 2021

Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

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7 January 2021

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

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7 January 2021

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

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7 January 2021

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis

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7 January 2021

Murine numb regulates granule cell maturation in the cerebellum

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7 January 2021

Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization

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7 January 2021

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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7 January 2021

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice

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7 January 2021

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

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7 January 2021

Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain

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7 January 2021

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects

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7 January 2021

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear

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7 January 2021

The Notch-Hes pathway in mammalian neural development

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7 January 2021

HES and HERP families: multiple effectors of the Notch signaling pathway

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7 January 2021

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

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7 January 2021

Up a notch: instructing gliogenesis

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7 January 2021

Nuclear Notch1 signaling and the regulation of dendritic development

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7 January 2021

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

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7 January 2021

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

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7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

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7 January 2021

Involvement of Notch signaling in hippocampal synaptic plasticity

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7 January 2021

Learning and memory deficits in Notch mutant mice.

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7 January 2021

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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7 January 2021

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

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7 January 2021

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

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7 January 2021

Proneural genes and the specification of neural cell types

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7 January 2021

Asymmetric cell division.

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7 January 2021

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

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7 January 2021

Protein degradation: four E3s for the notch pathway

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7 January 2021

An overview of the Notch signalling pathway

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7 January 2021

Glycosylation regulates Notch signalling.

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7 January 2021

The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.

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7 January 2021

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

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7 January 2021

Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

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7 January 2021

rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells

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7 January 2021

A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation

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7 January 2021

Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation

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7 January 2021

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

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7 January 2021

The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain

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7 January 2021

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

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7 January 2021

Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation

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7 January 2021

Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex

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7 January 2021

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

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7 January 2021

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

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7 January 2021

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

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7 January 2021

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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7 January 2021

Diversifying neural cells through order of birth and asymmetry of division

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7 January 2021

Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

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7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

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7 January 2021

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

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7 January 2021

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

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7 January 2021

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

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7 January 2021

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

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7 January 2021

A role for Abl in Notch signaling.

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7 January 2021

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain

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7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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7 January 2021

Identifiers

DOI

10.1038/NN1475

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Dimensions Publication ID

12 August 2017

1006282544

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