(Q35105866)

6 August 2017

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title

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex (English)

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6 August 2017

Bart De Strooper

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6 August 2017

language of work or name

English

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publication date

1 April 2003

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

9-12

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A cell biological perspective on Alzheimer's disease

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900205-8

7 January 2021

10.1016/S0896-6273(03)00205-8

Identifiers

DOI

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6 August 2017

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