(Q35695170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma (English)

1 reference

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25 December 2019

1 reference

1 reference

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25 December 2019

William Lewis

1 reference

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25 December 2019

Brian J Day

1 reference

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25 December 2019

James J Kohler

1 reference

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25 December 2019

Seyed H Hosseini

1 reference

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25 December 2019

Sherine S L Chan

1 reference

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25 December 2019

Elgin C Green

1 reference

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25 December 2019

Chad P Haase

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Erin S Keebaugh

1 reference

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25 December 2019

Robert Long

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Tomika Ludaway

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Rodney Russ

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Jeffrey Steltzer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Nina Tioleco

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Robert Santoianni

1 reference

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25 December 2019

publication date

19 February 2006

1 reference

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25 December 2019

published in

Laboratory Investigation

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25 December 2019

volume

1 reference

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25 December 2019

issue

1 reference

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25 December 2019

page(s)

326-335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma.

25 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

DNA polymerase gamma in mitochondrial DNA replication and repair.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

DNA polymerase gamma, the mitochondrial replicase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Premature ageing in mice expressing defective mitochondrial DNA polymerase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Inherited mitochondrial DNA depletion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Role of adenine nucleotide translocator 1 in mtDNA maintenance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Remodeling the cardiac sarcomere using transgenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial myopathy caused by long-term zidovudine therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Use of the transgenic mouse in models of AIDS cardiomyopathy.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular dystrophy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Defects of intergenomic communication: autosomal disorders that cause multiple deletions and depletion of mitochondrial DNA.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1831462

Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine

15 November 2018

1 reference

12 December 2020

Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations

1 reference

12 December 2020

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

1 reference

12 December 2020

The relationship between somatic mtDNA rearrangements, human heart disease and aging

1 reference

12 December 2020

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

1 reference

12 December 2020

Gene expression profile in dilated cardiomyopathy caused by elevated frequencies of mitochondrial DNA mutations in the mouse heart

1 reference

12 December 2020

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart

1 reference

12 December 2020

10.1038/LABINVEST.3700523

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

17310215

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17310215%20AND%20SRC:MED&resulttype=core&format=json