(Q35550221)

8 August 2017

1 reference

title

Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective (English)

1 reference

8 August 2017

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective (English)

1 reference

highly active antiretroviral therapy

17 March 2024

main subject

toxicity

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526384

17 March 2024

1 reference

17 March 2024

Brian J. Day

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526384

17 March 2024

William C. Copeland

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526384

17 March 2024

William Lewis

1 reference

8 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14526384

17 March 2024

publication date

1 October 2003

1 reference

full work available at URL

8 August 2017

http://www.nature.com/articles/nrd1201.pdf

file format

Portable Document Format

1 reference

http://www.nature.com/articles/nrd1201

17 March 2024

1 reference

Nature Reviews Drug Discovery

17 March 2024

published in

1 reference

8 August 2017

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8 August 2017

1 reference

8 August 2017

page(s)

812-822

1 reference

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

8 August 2017

cites work

1 reference

Mitochondrial myopathy caused by long-term zidovudine therapy

31 March 2020

1 reference

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

31 March 2020

1 reference

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

31 March 2020

1 reference

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

31 March 2020

1 reference

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

31 March 2020

1 reference

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

31 March 2020

1 reference

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate

31 March 2020

1 reference

Mitochondrial toxicity of antiviral drugs

31 March 2020

1 reference

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

31 March 2020

1 reference

3′-Azido-3′-deoxythymidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator

31 March 2020

1 reference

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

31 March 2020

1 reference

Cellular targets of 3′-azido-3′-deoxythymidine: an early (non-delayed) effect on oxidative phosphorylation

31 March 2020

1 reference

Is the failing heart energy depleted?

31 March 2020

1 reference

Mitochondrial oxidative stress in heart failure: "oxygen wastage" revisited

31 March 2020

1 reference

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

31 March 2020

1 reference

Diseases of the mitochondrial DNA.

31 March 2020

1 reference

Changes in the human mitochondrial genome after treatment of malignant disease

31 March 2020

1 reference

Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses

31 March 2020

1 reference

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*

31 March 2020

1 reference

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

31 March 2020

1 reference

Evaluation of mitochondrial DNA content and enzyme levels in tenofovir DF-treated rats, rhesus monkeys and woodchucks

31 March 2020

1 reference

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

31 March 2020

1 reference

Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndrome

31 March 2020

1 reference

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

31 March 2020

1 reference

Renal lesions in HIV-1-positive patient treated with tenofovir

31 March 2020

1 reference

31 March 2020

1 reference

Drug-induced renal failure: update on new medications and unique mechanisms of nephrotoxicity

31 March 2020

1 reference

Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta).

31 March 2020

1 reference

Mitochondria as Cell Targets of AZT (Zidovudine)

31 March 2020

1 reference

Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

31 March 2020

1 reference

Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

31 March 2020

1 reference

Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis

31 March 2020

1 reference

Mitochondrial DNA and nucleoside toxicity

31 March 2020

1 reference

Mitochondrial Injury Lessons from the Fialuridine Trial

31 March 2020

1 reference

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

31 March 2020

1 reference

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

31 March 2020

1 reference

Nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity as an etiology for lipodystrophy

31 March 2020

1 reference

Mitochondrial DNA replication, nucleoside reverse-transcriptase inhibitors, and AIDS cardiomyopathy

31 March 2020

1 reference

Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy

31 March 2020

1 reference

Cardiomyopathy in AIDS: a pathophysiological perspective

31 March 2020

1 reference

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

31 March 2020

1 reference

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

31 March 2020

1 reference

Mitochondrial targets of drug toxicity

31 March 2020

1 reference

Mammalian deoxyribonucleoside kinases

31 March 2020

1 reference

Characterization of human deoxycytidine kinase. Correlation with cDNA sequences

31 March 2020

1 reference

Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs

31 March 2020

1 reference

Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase

31 March 2020

1 reference

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

31 March 2020

1 reference

Molecular targets for AIDS therapy

31 March 2020

1 reference

Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease

31 March 2020

1 reference

Mitochondrial carrier proteins

31 March 2020

1 reference

The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals

31 March 2020

1 reference

Mitochondrial biogenesis defects and neuromuscular disorders

31 March 2020

1 reference

Clinical manifestations of mitochondrial DNA depletion

31 March 2020

1 reference

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

31 March 2020

1 reference

Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

31 March 2020

1 reference

Molecular mechanisms in mitochondrial DNA depletion syndrome

31 March 2020

1 reference

Mitochondrial toxicity--new adverse drug effects

31 March 2020

1 reference

Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

31 March 2020

1 reference

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

31 March 2020

1 reference

Submitochondrial localization and characteristics of thymidine kinase molecular forms in parental and kinase-deficient hela cells

31 March 2020

1 reference

Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA

31 March 2020

1 reference

Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform

31 March 2020

1 reference

The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA

31 March 2020

1 reference

The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance

31 March 2020

1 reference

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

31 March 2020

1 reference

Efficient Incorporation of Anti-HIV Deoxynucleotides by Recombinant Yeast Mitochondrial DNA Polymerase

31 March 2020

1 reference

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

31 March 2020

1 reference

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

31 March 2020

1 reference

Error rate and specificity of human and murine DNA polymerase eta

31 March 2020

1 reference

Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs

31 March 2020

1 reference

Stringent and relaxed specificities of TaqI endonuclease: interactions with metal cofactors and DNA sequences

31 March 2020

1 reference

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

31 March 2020

1 reference

Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

31 March 2020

1 reference

Mitochondrial diseases in man and mouse

31 March 2020

1 reference

Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver

31 March 2020

1 reference

Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.

31 March 2020

1 reference

Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization

31 March 2020

1 reference

Influence of template primary structure on 3'-azido-3'-deoxythymidine triphosphate incorporation into DNA

31 March 2020

1 reference

Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells

31 March 2020

1 reference

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

31 March 2020

1 reference

Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis

31 March 2020

1 reference

Mitochondrial disease in mouse results in increased oxidative stress

31 March 2020

1 reference

Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT)

31 March 2020

1 reference

Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats

31 March 2020

1 reference

Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine

31 March 2020

1 reference

Genotoxic activity of azidothymidine (AZT) in in vitro systems

31 March 2020

1 reference

Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

31 March 2020

1 reference

Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

31 March 2020

1 reference

Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

31 March 2020

1 reference

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

31 March 2020

1 reference

Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside-analogue reverse-transcriptase inhibitors

31 March 2020

1 reference

Mutation analysis in 16 patients with mtDNA depletion.

31 March 2020

1 reference

Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts

31 March 2020

1 reference

Natural selection shaped regional mtDNA variation in humans

31 March 2020

1 reference

Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma

31 March 2020

1 reference

Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

31 March 2020

1 reference

Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

31 March 2020

1 reference

An objective case definition of lipodystrophy in HIV-infected adults: a case-control study

31 March 2020

1 reference

Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat.

31 March 2020

1 reference

Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy

31 March 2020

1 reference

Mitochondrial involvement in antiretroviral therapy-related lipodystrophy

31 March 2020

1 reference

Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: actors or bystanders?

31 March 2020

1 reference

Tests for mitochondrial function and DNA: potentials and pitfalls

31 March 2020

1 reference

What is oxidative stress?

31 March 2020

1 reference

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

31 March 2020

1 reference

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

31 March 2020

1 reference

Mitochondrial formation of OH Radicals by an ubisemiquinone-dependent reaction an alternative pathway to the iron-catalysed Haber-Weiss cycle

31 March 2020

1 reference

Reactive oxygen species produced by liver mitochondria of rats in sepsis.

31 March 2020

1 reference

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state

31 March 2020

1 reference

The mitochondrial DNA polymerase as a target of oxidative damage

31 March 2020

1 reference

Liposome-mediated augmentation of catalase in alveolar type II cells protects against H2O2 injury

31 March 2020

1 reference

Immunolocalization of cellular glutathione peroxidase in adult rat lungs and quantitative analysis after postembedding immunogold labeling

31 March 2020

1 reference

Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydroperoxides

31 March 2020

1 reference

The importance of free radicals and catalytic metal ions in human diseases

31 March 2020

1 reference

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

31 March 2020

1 reference

Inhibition of phosphate transport in rat heart mitochondria by 3'-azido-3'-deoxythymidine due to stimulation of superoxide anion mitochondrial production

31 March 2020

1 reference

Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice

31 March 2020

1 reference

Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells

31 March 2020

1 reference

The Human Immunodeficiency Virus Type 1 Tat Protein Potentiates Zidovudine-Induced Cellular Toxicity In Transgenic Mice

31 March 2020

1 reference

Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage.

31 March 2020

1 reference

Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment.

31 March 2020

1 reference

Regulation of mitogenesis by kinins in arterial smooth muscle cells

31 March 2020

1 reference

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

31 March 2020

1 reference

Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress

31 March 2020

1 reference

A Manganese Superoxide Dismutase (SOD2) Gene Polymorphism in Insulin-Dependent Diabetes Mellitus

31 March 2020

1 reference

Ethnic variation in the mitochondrial targeting sequence polymorphism of MnSOD.

31 March 2020

1 reference

The development of mitochondrial medicine

31 March 2020

1 reference

Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis

31 March 2020

1 reference

The expanding spectrum of nuclear gene mutations in mitochondrial disorders

31 March 2020

1 reference

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

31 March 2020

1 reference

31 March 2020

Molecular Pharmacology

625

CH Chen

1991

1 reference

17 March 2024

Molecular Pharmacology

K Bebenek

1993

1 reference

17 March 2024

Identifiers

DOI

10.1038/NRD1201

1 reference

Dimensions Publication ID

8 August 2017

1002739069

0 references

Fatcat ID

release_bbtrhqrqjnedfbimilbmdcjrxm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bbtrhqrqjnedfbimilbmdcjrxm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference