(Q35659640)

9 August 2017

title

Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer (English)

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9 August 2017

W Marston Linehan

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9 August 2017

Tracey A Rouault

series ordinal

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9 August 2017

language of work or name

English

0 references

publication date

30 April 2013

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9 August 2017

published in

Clinical Cancer Research

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

3345-3352

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

9 August 2017

cites work

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Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome

12 July 2018

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Englerin a selectively induces necrosis in human renal cancer cells

12 July 2018

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12 July 2018

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A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer

12 July 2018

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

12 July 2018

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12 July 2018

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Targeting glucose metabolism for cancer therapy

12 July 2018

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Chlorinated englerins with selective inhibition of renal cancer cell growth

12 July 2018

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Reductive carboxylation supports growth in tumour cells with defective mitochondria.

12 July 2018

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Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

12 July 2018

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

12 July 2018

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An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

12 July 2018

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

12 July 2018

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The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

12 July 2018

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

12 July 2018

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

12 July 2018

1 reference

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Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

12 July 2018

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Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma

12 July 2018

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Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

12 July 2018

1 reference

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UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

12 July 2018

1 reference

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Cysteine-based regulation of the CUL3 adaptor protein Keap1

12 July 2018

1 reference

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

12 July 2018

1 reference

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LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

12 July 2018

1 reference

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Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

12 July 2018

1 reference

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Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

12 July 2018

1 reference

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Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress

12 July 2018

1 reference

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The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

12 July 2018

1 reference

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Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

12 July 2018

1 reference

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

12 July 2018

1 reference

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

12 July 2018

1 reference

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

A conserved family of prolyl-4-hydroxylases that modify HIF

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Inherited susceptibility to uterine leiomyomas and renal cell cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Parenchymal sparing surgery in patients with hereditary renal cell carcinoma: 10-year experience

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Hereditary papillary renal cell carcinoma: clinical studies in 10 families

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447120

Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome

25 September 2018

1 reference

12 December 2020

S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate

1 reference

12 December 2020

Multiple painful cutaneous nodules and renal mass

1 reference

12 December 2020

The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome

1 reference

12 December 2020

10.1158/1078-0432.CCR-13-0304

Identifiers

DOI

1 reference

9 August 2017

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9 August 2017

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