(Q44043145)

29 November 2017

title

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein (English)

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29 November 2017

William G Kaelin

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29 November 2017

Keiichi Kondo

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29 November 2017

Jeff Klco

series ordinal

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29 November 2017

Eijiro Nakamura

series ordinal

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29 November 2017

Mirna Lechpammer

series ordinal

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29 November 2017

publication date

1 April 2002

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29 November 2017

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29 November 2017

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29 November 2017

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29 November 2017

page(s)

237-246

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Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

29 November 2017

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Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma

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7 January 2021

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

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7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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7 January 2021

Oncogenic alterations of metabolism

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7 January 2021

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

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7 January 2021

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

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7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

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7 January 2021

Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

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7 January 2021

Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC

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7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

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7 January 2021

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

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7 January 2021

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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7 January 2021

Tumour suppression by the human von Hippel-Lindau gene product

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7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

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7 January 2021

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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7 January 2021

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

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7 January 2021

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells

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7 January 2021

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

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7 January 2021

Epidermal growth factor in the normal and neoplastic kidney and bladder

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7 January 2021

Membranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous system.

1 reference

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7 January 2021

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

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7 January 2021

von Hippel-Lindau disease

1 reference

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7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Vascular endothelial growth factor expression is increased in renal cell carcinoma

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7 January 2021

Microvessel quantitation in invasive breast cancer by staining for factor VIII-related antigen

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7 January 2021

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

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7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

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7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

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7 January 2021

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

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7 January 2021

Differential response to transforming growth factor (TGF)-alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types

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7 January 2021

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

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7 January 2021

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

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7 January 2021

Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900043-0

7 January 2021

10.1016/S1535-6108(02)00043-0

Identifiers

DOI

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29 November 2017

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