(Q35164198)

6 August 2017

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title

The establishment and maintenance of lymphocyte identity through gene silencing (English)

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6 August 2017

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Stephen T Smale

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6 August 2017

language of work or name

English

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publication date

1 July 2003

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

607-615

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Cellular identity and lineage choice

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Gene silencing, cell fate and nuclear organisation

21 January 2018

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Heterochromatin: new possibilities for the inheritance of structure

21 January 2018

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The regulation of CD4 and CD8 coreceptor gene expression during T cell development

21 January 2018

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Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

21 January 2018

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The lineage decisions of helper T cells

21 January 2018

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Molecular mechanisms regulating Th1 immune responses

21 January 2018

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Chromatin structure and gene regulation in the immune system

21 January 2018

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Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects

21 January 2018

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Maintenance of chromatin states: an open-and-shut case

21 January 2018

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DNA methylation patterns and epigenetic memory

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

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Histone methylation in transcriptional control

21 January 2018

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The many faces of histone lysine methylation

21 January 2018

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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

21 January 2018

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Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

21 January 2018

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Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

21 January 2018

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Positions of potential: nuclear organization and gene expression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Domain organization at the centromere and neocentromere

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

21 January 2018

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Breaking through to the other side: silencers and barriers

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.

21 January 2018

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Establishment and maintenance of a heterochromatin domain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Unfolding the mysteries of heterochromatin.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Replication timing and transcriptional control: beyond cause and effect

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The notch pathway intermediate HES-1 silences CD4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Subclass-specific nuclear localization of a novel CD4 silencer binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Negative regulation of CD4 gene expression by a HES-1-c-Myb complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FNI0703-607

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Mechanisms of transcriptional regulation by Runt domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Mechanisms of transcriptional memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Chromatin silencing and activation by Polycomb and trithorax group proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Polycomb-group genes as regulators of mammalian lymphopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Stabilization of chromatin structure by PRC1, a Polycomb complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

SATB1 targets chromatin remodelling to regulate genes over long distances

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Haematopoietic cell-fate decisions, chromatin regulation and ikaros

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

The CD8alpha gene locus is regulated by the Ikaros family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

A gap gene, hunchback, regulates the spatial expression of Ultrabithorax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

dMi-2, a hunchback-interacting protein that functions in polycomb repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Gene silencing quantitatively controls the function of a developmental trans-activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Kappa chain monoallelic demethylation and the establishment of allelic exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

X Inactivation in the Mouse Embryo Deficient for Dnmt1: Distinct Effect of Hypomethylation on Imprinted and Random X Inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

Nuclear organization and silencing: putting things in their place

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Molecular biology. An RNA-guided pathway for the epigenome

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Locus control region function and heterochromatin-induced position effect variegation

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

A transcriptional silencer controls the developmental expression of the CD4 gene.

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Asymmetric redundancy in CD4 silencer function

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Imprinted X inactivation maintained by a mouse Polycomb group gene

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Methylated and unmethylated DNA compartments in the sea urchin genome

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1038%2FNI0703-607

7 January 2021

Identifiers

DOI

10.1038/NI0703-607

1 reference

6 August 2017

1 reference