(Q34716329)

4 August 2017

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title

Suppressors of cytokine signalling (SOCS) in the immune system (English)

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4 August 2017

Warren S Alexander

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4 August 2017

publication date

1 June 2002

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Nature Reviews Immunology

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

410-416

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Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

4 August 2017

cites work

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Cytokine receptor signalling

31 March 2020

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Negative regulation of Janus kinases

31 March 2020

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Negative regulation of the JAK/STAT pathway

31 March 2020

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Twenty proteins containing a C-terminal SOCS box form five structural classes

31 March 2020

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Structure and function of a new STAT-induced STAT inhibitor

31 March 2020

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A family of cytokine-inducible inhibitors of signalling

31 March 2020

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A new protein containing an SH2 domain that inhibits JAK kinases

31 March 2020

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Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

31 March 2020

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

31 March 2020

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

31 March 2020

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

31 March 2020

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

31 March 2020

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Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

31 March 2020

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SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

31 March 2020

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

31 March 2020

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

31 March 2020

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

31 March 2020

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

31 March 2020

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Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.

31 March 2020

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Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein

31 March 2020

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

31 March 2020

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

31 March 2020

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

31 March 2020

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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

31 March 2020

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Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice

31 March 2020

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

31 March 2020

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Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

31 March 2020

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

31 March 2020

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Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease

31 March 2020

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

31 March 2020

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Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transductionin Vitroandin Vivo

31 March 2020

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SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

31 March 2020

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The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene

31 March 2020

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Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

31 March 2020

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Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

31 March 2020

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Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

31 March 2020

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SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line

31 March 2020

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Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells

31 March 2020

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

31 March 2020

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Gigantism in mice lacking suppressor of cytokine signalling-2

31 March 2020

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

31 March 2020

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B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

31 March 2020

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CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

31 March 2020

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Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

31 March 2020

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Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

31 March 2020

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CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling

31 March 2020

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Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling

31 March 2020

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IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3

31 March 2020

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Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

31 March 2020

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Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

31 March 2020

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Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*.

31 March 2020

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Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues

31 March 2020

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Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl

31 March 2020

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SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

31 March 2020

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Mechanism of STAT3 activation by insulin-like growth factor I receptor

31 March 2020

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JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

31 March 2020

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Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

31 March 2020

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Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo

31 March 2020

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Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

31 March 2020

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Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal

31 March 2020

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Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

31 March 2020

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The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

31 March 2020

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Cloning and Functional Analysis of New Members of STAT Induced STAT Inhibitor (SSI) Family: SSI-2 and SSI-3

31 March 2020

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Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

31 March 2020

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Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis

31 March 2020

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Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity

31 March 2020

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Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

31 March 2020

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The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.

31 March 2020

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Identification of SOCS-3 as a potential mediator of central leptin resistance

31 March 2020

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Tumor necrosis factor alpha attenuates interferon alpha signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy.

31 March 2020

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Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

31 March 2020

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SOCS-3 is an insulin-induced negative regulator of insulin signaling

31 March 2020

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Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI818

0 references

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