(Q34716347)

4 August 2017

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title

T-cell signalling and autoimmunity: molecular mechanisms of disease (English)

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4 August 2017

Pamela S Ohashi

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4 August 2017

publication date

1 June 2002

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Nature Reviews Immunology

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

427-438

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Checkpoints in the progression of autoimmune disease: lessons from diabetes models

4 August 2017

cites work

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Cytokines that regulate autoimmune responses.

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Cytokines and autoimmunity

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Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

31 March 2020

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Genetic remodeling of protein glycosylation in vivo induces autoimmune disease

31 March 2020

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The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.

31 March 2020

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Role of cyclin kinase inhibitor p21 in systemic autoimmunity.

31 March 2020

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Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

31 March 2020

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T cell selection and autoimmunity: flexibility and tuning

31 March 2020

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Selection of the T cell repertoire.

31 March 2020

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Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

31 March 2020

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Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

31 March 2020

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Ligand thresholds at different stages of T cell development

31 March 2020

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Homeostasis of alpha beta TCR+ T cells.

31 March 2020

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Homeostatic T cell proliferation: how far can T cells be activated to self-ligands?

31 March 2020

1 reference

Cross-presentation: a general mechanism for CTL immunity and tolerance

31 March 2020

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Dendritic cells and the control of immunity

31 March 2020

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Sensing pathogens and tuning immune responses

31 March 2020

1 reference

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

31 March 2020

1 reference

Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

31 March 2020

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Role of antigen-presenting cells in mediating tolerance and autoimmunity

31 March 2020

1 reference

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

31 March 2020

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Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

31 March 2020

1 reference

Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease

31 March 2020

1 reference

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

31 March 2020

1 reference

MHC structure and autoimmune T cell repertoire development

31 March 2020

1 reference

Autoimmune disease: why and where it occurs.

31 March 2020

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

31 March 2020

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Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

31 March 2020

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Cross-presentation, dendritic cells, tolerance and immunity

31 March 2020

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CD95's deadly mission in the immune system

31 March 2020

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The role of fas ligand in vivo as a cause and regulator of pathogenesis

31 March 2020

1 reference

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

31 March 2020

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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

31 March 2020

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Longevity of Antigen Presentation and Activation Status of APC Are Decisive Factors in the Balance Between CTL Immunity Versus Tolerance

31 March 2020

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Limit of T cell tolerance to self proteins by peptide presentation

31 March 2020

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Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

31 March 2020

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Molecular mimicry and autoimmune disease

31 March 2020

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

31 March 2020

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Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

31 March 2020

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Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

31 March 2020

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Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

31 March 2020

1 reference

Regulatory T cells in autoimmmunity*.

31 March 2020

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Molecular basis of the motheaten phenotype

31 March 2020

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Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

31 March 2020

1 reference

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

31 March 2020

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A point mutation in PTPRC is associated with the development of multiple sclerosis

31 March 2020

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A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer

31 March 2020

1 reference

Cbl: many adaptations to regulate protein tyrosine kinases

31 March 2020

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

31 March 2020

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

31 March 2020

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

31 March 2020

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

31 March 2020

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Cbl-b regulates the CD28 dependence of T-cell activation.

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

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Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation

31 March 2020

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Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity

31 March 2020

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

31 March 2020

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

31 March 2020

1 reference

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Impaired Fas response and autoimmunity in Pten+/- mice

31 March 2020

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

31 March 2020

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Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide

31 March 2020

1 reference

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

31 March 2020

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Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells

31 March 2020

1 reference

The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.

31 March 2020

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Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

31 March 2020

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Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1)

31 March 2020

1 reference

Fas and Fas ligand: lpr and gld mutations

31 March 2020

1 reference

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

31 March 2020

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Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

31 March 2020

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Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Direct control of the Forkhead transcription factor AFX by protein kinase B

31 March 2020

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

31 March 2020

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Negative regulation of the forkhead transcription factor FKHR by Akt.

31 March 2020

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

1 reference

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

31 March 2020

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

31 March 2020

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

31 March 2020

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

31 March 2020

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Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

31 March 2020

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

31 March 2020

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Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

31 March 2020

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Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

31 March 2020

1 reference

The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

31 March 2020

1 reference

Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes.

31 March 2020

1 reference

Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.

31 March 2020

1 reference

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development

31 March 2020

1 reference

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

31 March 2020

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NFATc1 and NFATc2 together control both T and B cell activation and differentiation

31 March 2020

1 reference

Solution structure of the PX domain, a target of the SH3 domain

31 March 2020

1 reference

Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides

31 March 2020

1 reference

Cellular signaling: pivoting around PDK-1.

31 March 2020

1 reference

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

31 March 2020

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

Regulation of the immune response by SHIP.

31 March 2020

1 reference

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

31 March 2020

1 reference

Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

31 March 2020

1 reference

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

31 March 2020

1 reference

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

31 March 2020

1 reference

Vav regulates peptide-specific apoptosis in thymocytes

31 March 2020

1 reference

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI822

0 references

1 reference