(Q46113259)

19 December 2017

title

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity (English)

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19 December 2017

author name string

Majeti R

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19 December 2017

Xu Z

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19 December 2017

Parslow TG

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19 December 2017

Olson JL

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19 December 2017

Daikh DI

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19 December 2017

Killeen N

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19 December 2017

Weiss A

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19 December 2017

language of work or name

English

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publication date

1 December 2000

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19 December 2017

published in

Cell

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19 December 2017

volume

103

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19 December 2017

issue

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19 December 2017

page(s)

1059-1070

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19 December 2017

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

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Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

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Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

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Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase

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7 January 2021

Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development

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7 January 2021

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

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7 January 2021

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7 January 2021

CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development

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7 January 2021

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus

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7 January 2021

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli

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7 January 2021

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

19 December 2017

1 reference

19 December 2017