(Q34126053)

31 July 2017

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title

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway (English)

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31 July 2017

John J O'Shea

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31 July 2017

Massimo Gadina

series ordinal

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31 July 2017

Robert D Schreiber

series ordinal

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31 July 2017

language of work or name

English

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publication date

1 April 2002

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31 July 2017

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31 July 2017

volume

109 Suppl

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31 July 2017

page(s)

S121-31

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Roles of STAT3 defined by tissue-specific gene targeting

31 July 2017

cites work

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7 January 2021

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

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7 January 2021

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

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7 January 2021

A profound deficiency in thymic progenitor cells in mice lacking Jak3.

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7 January 2021

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain

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7 January 2021

Interleukin 20: discovery, receptor identification, and role in epidermal function

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7 January 2021

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7 January 2021

The role of STATs in transcriptional control and their impact on cellular function

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7 January 2021

Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless

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7 January 2021

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

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7 January 2021

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

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7 January 2021

Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains

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7 January 2021

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

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7 January 2021

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

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7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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7 January 2021

Serine phosphorylation of STATs

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7 January 2021

Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation

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7 January 2021

STAM2, a new member of the STAM family, binding to the Janus kinases

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7 January 2021

Role of nucleoporin induction in releasing an mRNA nuclear export block

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7 January 2021

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

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7 January 2021

Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

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7 January 2021

IFN-gamma production by antigen-presenting cells: mechanisms emerge.

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7 January 2021

Unexpected and variable phenotypes in a family with JAK3 deficiency

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7 January 2021

Tyrosine phosphorylation-independent nuclear translocation of a dictyostelium STAT in response to DIF signaling

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7 January 2021

Biologic consequences of Stat1-independent IFN signaling.

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7 January 2021

An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

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7 January 2021

Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice

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7 January 2021

Designing small-molecule switches for protein-protein interactions

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

STAT proteins and transcriptional responses to extracellular signals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The Stat family in cytokine signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Partial impairment of cytokine responses in Tyk2-deficient mice

1 reference

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7 January 2021

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

1 reference

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7 January 2021

Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

SOCS proteins: negative regulators of cytokine signaling

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Distinct requirements for IFNs and STAT1 in NK cell function

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7 January 2021

STAT4 and STAT6 regulate systemic inflammation and protect against lethal endotoxemia

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7 January 2021

Jaks and STATs: biological implications

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7 January 2021

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

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7 January 2021

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

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7 January 2021

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

STAT1 from the cell membrane to the DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Gigantism in mice lacking suppressor of cytokine signalling-2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

SH2-B family members differentially regulate JAK family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Transcriptional regulation in lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Immune response in Stat2 knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Stat1-independent regulation of gene expression in response to IFN-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Modulation of STAT signaling by STAT-interacting proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

A new IFN-like cytokine, limitin, modulates the immune response without influencing thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

STAT signalling in cell proliferation and in development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The biology of Stat4 and Stat6

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Negative regulation of cytokine signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The roles of the Drosophila JAK/STAT pathway

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900701-8

7 January 2021

10.1016/S0092-8674(02)00701-8

Identifiers

DOI

1 reference

31 July 2017

1 reference