(Q43821324)

27 November 2017

title

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases (English)

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27 November 2017

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27 November 2017

Y J Zhou

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27 November 2017

M Chen

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27 November 2017

N A Cusack

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27 November 2017

L H Kimmel

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27 November 2017

K S Magnuson

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27 November 2017

J G Boyd

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27 November 2017

W Lin

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27 November 2017

J L Roberts

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27 November 2017

A Lengi

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27 November 2017

R H Buckley

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27 November 2017

F Candotti

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27 November 2017

M Gadina

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27 November 2017

P S Changelian

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27 November 2017

J J O'Shea

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27 November 2017

publication date

1 November 2001

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27 November 2017

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27 November 2017

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27 November 2017

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27 November 2017

page(s)

959-969

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Development of inhibitors for protein tyrosine kinases

27 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Selected glimpses into the activation and function of Src kinase

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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Affinity labeling of the nucleotide-binding site of myosin light chain kinases

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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Multiple sequence alignment with hierarchical clustering

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Signaling by type I and II cytokine receptors: ten years after

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Signaling by the cytokine receptor superfamily

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https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Jaks and STATs: biological implications

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Defective lymphoid development in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Jaks and stats as therapeutic targets

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Signaling network of the Btk family kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

A conserved helix motif complements the protein kinase core

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2801%2900398-7

7 January 2021

10.1016/S1097-2765(01)00398-7

Identifiers

DOI

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27 November 2017

1 reference