(Q34045444)

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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication

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Europe PubMed Central

PubMed publication ID

30 July 2017

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

Hepatitis C virus

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David N Frick

13

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Donald F Smee

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30 July 2017

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John D Morrey

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30 July 2017

author name string

Angela M Lam

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30 July 2017

Eisuke Murakami

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30 July 2017

Christine Espiritu

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30 July 2017

Holly M Micolochick Steuer

4

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30 July 2017

Congrong Niu

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30 July 2017

Meg Keilman

6

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30 July 2017

Haiying Bao

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30 July 2017

Veronique Zennou

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30 July 2017

Nigel Bourne

9

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30 July 2017

Justin G Julander

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30 July 2017

Julie A Heck

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30 July 2017

Peiyuan Wang

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30 July 2017

Dhanapalan Nagarathnam

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30 July 2017

Bruce S Ross

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30 July 2017

Michael J Sofia

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30 July 2017

Michael J Otto

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30 July 2017

Phillip A Furman

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language of work or name

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publication date

1 June 2010

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30 July 2017

Antimicrobial Agents and Chemotherapy

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30 July 2017

54

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30 July 2017

8

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30 July 2017

3187-3196

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30 July 2017

Identification of Hepatitis C Virus NS5A Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

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Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.

1 reference

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5 July 2018

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

1 reference

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5 July 2018

Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors

1 reference

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5 July 2018

Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors

1 reference

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5 July 2018

NS5A--from obscurity to new target for HCV therapy

1 reference

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Resistance mechanisms in HCV: from evolution to intervention

1 reference

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5 July 2018

Hepatitis C virus therapy to date.

1 reference

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5 July 2018

Effects of Mutagenic and Chain-Terminating Nucleotide Analogs on Enzymes Isolated from Hepatitis C Virus Strains of Various Genotypes

1 reference

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5 July 2018

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

1 reference

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5 July 2018

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

5 July 2018

Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

5 July 2018

Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

5 July 2018

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

5 July 2018

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916354

5 July 2018

In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance

1 reference

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5 July 2018

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

1 reference

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5 July 2018

Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase

1 reference

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5 July 2018

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

1 reference

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5 July 2018

Screening for hepatitis C virus antiviral activity with a cell-based secreted alkaline phosphatase reporter replicon system

1 reference

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5 July 2018

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay

1 reference

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5 July 2018

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

1 reference

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5 July 2018

Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells

1 reference

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5 July 2018

Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose

1 reference

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5 July 2018

Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon

1 reference

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5 July 2018

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

1 reference

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5 July 2018

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

1 reference

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5 July 2018

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

1 reference

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5 July 2018

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

1 reference

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5 July 2018

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

1 reference

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5 July 2018

Subgenomic hepatitis C virus replicons inducing expression of a secreted enzymatic reporter protein

1 reference

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1 reference

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1 reference

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Involvement of DNA polymerase delta and/or epsilon in joining UV-induced DNA single strand breaks in human fibroblasts (comparison of effects of butylphenyldeoxyguanosine with aphidicolin)

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10.1128/AAC.00399-10

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Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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