(Q33941017)

30 July 2017

title

In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence (English)

1 reference

30 July 2017

Zoya Ignatova

0 references

Ashwani K Thakur

1 reference

30 July 2017

Ronald Wetzel

series ordinal

1 reference

30 July 2017

Lila M Gierasch

series ordinal

1 reference

30 July 2017

language of work or name

English

0 references

publication date

17 October 2007

1 reference

Journal of Biological Chemistry

30 July 2017

published in

1 reference

30 July 2017

volume

282

1 reference

30 July 2017

1 reference

30 July 2017

page(s)

36736-36743

1 reference

Quantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theories

30 July 2017

cites work

1 reference

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The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model

5 July 2018

1 reference

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Amyloid-linked cellular toxicity triggered by bacterial inclusion bodies

5 July 2018

1 reference

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Polymorphism in the intermediates and products of amyloid assembly

5 July 2018

1 reference

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The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

A century-old debate on protein aggregation and neurodegeneration enters the clinic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Screening for modulators of aggregation with a microplate elongation assay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Flanking sequences profoundly alter polyglutamine toxicity in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Opinion: What is the role of protein aggregation in neurodegeneration?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Aggregation of a slow-folding mutant of a beta-clam protein proceeds through a monomeric nucleus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Protein aggregation and neurodegenerative disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

A linear lattice model for polyglutamine in CAG-expansion diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Fluorescent labeling of recombinant proteins in living cells with FlAsH.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Glutamine repeats and neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Immunolocalization of cellular retinol-, retinaldehyde- and retinoic acid-binding proteins in rat retina during pre- and postnatal development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Amyloid-like properties of bacterial inclusion bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Nativelike secondary structure in interleukin-1 beta inclusion bodies by attenuated total reflectance FTIR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Conformational diversity in a yeast prion dictates its seeding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Investigating the structural properties of amyloid-like fibrils formed in vitro from beta2-microglobulin using limited proteolysis and electrospray ionisation mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Characterizing the conformational ensemble of monomeric polyglutamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Solution structure of polyglutamine tracts in GST-polyglutamine fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Huntington aggregates may not predict neuronal death in Huntington's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892112

Mechanisms of Ataxin-3 Misfolding and Fibril Formation: Kinetic Analysis of a Disease-associated Polyglutamine Protein

29 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703682200

Structural features of the Abeta amyloid fibril elucidated by limited proteolysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A toxic monomeric conformer of the polyglutamine protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17942400

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M703682200

1 reference

30 July 2017

1 reference

30 July 2017

1 reference