(Q28273600)

27 March 2017

1 reference

1 reference

Christopher A Ross

1 reference

27 March 2017

Michelle A Poirier

1 reference

27 March 2017

language of work or name

English

0 references

publication date

July 2004

1 reference

27 March 2017

1 reference

27 March 2017

volume

10 Suppl

0 references

1 reference

27 March 2017

issue

1 reference

27 March 2017

page(s)

S10-7

0 references

S10-S17

1 reference

Toxic proteins in neurodegenerative disease

27 March 2017

cites work

1 reference

7 January 2021

Huntingtin aggregation and toxicity in Huntington's disease

1 reference

7 January 2021

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

7 January 2021

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

1 reference

7 January 2021

The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases

1 reference

7 January 2021

Alzheimer's disease and Parkinson's disease

1 reference

7 January 2021

Genetically engineered mouse models of neurodegenerative diseases

1 reference

7 January 2021

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

1 reference

7 January 2021

Folding proteins in fatal ways

1 reference

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

7 January 2021

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

1 reference

7 January 2021

Neuropathological classification of Huntington's disease

1 reference

7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

1 reference

7 January 2021

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

7 January 2021

Clinical and neuropathologic assessment of severity in Huntington's disease

1 reference

7 January 2021

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

1 reference

7 January 2021

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

1 reference

7 January 2021

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

7 January 2021

Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases

1 reference

7 January 2021

SCA1 molecular genetics: a history of a 13 year collaboration against glutamines

1 reference

7 January 2021

Role of histidine interruption in mitigating the pathological effects of long polyglutamine stretches in SCA1: A molecular approach

1 reference

7 January 2021

Alzheimer's disease is a synaptic failure

1 reference

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

7 January 2021

Direct visualisation of the beta-sheet structure of synthetic Alzheimer's amyloid

1 reference

7 January 2021

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

7 January 2021

Alzheimer's disease: treatments in discovery and development

1 reference

7 January 2021

Tau protein and neurodegeneration

1 reference

7 January 2021

Tau gene mutations: dissecting the pathogenesis of FTDP-17.

1 reference

7 January 2021

Neuropathology of Parkinson's disease

1 reference

7 January 2021

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

1 reference

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

7 January 2021

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

7 January 2021

Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis

1 reference

7 January 2021

Shattuck lecture--neurodegenerative diseases and prions

1 reference

7 January 2021

Investigating protein conformation-based inheritance and disease in yeast

1 reference

7 January 2021

The elongation of yeast prion fibers involves separable steps of association and conversion

1 reference

7 January 2021

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

7 January 2021

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

1 reference

7 January 2021

X-ray diffraction studies on amyloid filaments

1 reference

7 January 2021

From the globular to the fibrous state: protein structure and structural conversion in amyloid formation.

1 reference

7 January 2021

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

1 reference

7 January 2021

Insights into the amyloid folding problem from solid-state NMR

1 reference

7 January 2021

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

1 reference

7 January 2021

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

1 reference

7 January 2021

Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR

1 reference

7 January 2021

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

1 reference

7 January 2021

Mutational analysis of the structural organization of polyglutamine aggregates

1 reference

7 January 2021

Polyglutamine fibrillogenesis: the pathway unfolds

1 reference

7 January 2021

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

1 reference

7 January 2021

Conformational Abs recognizing a generic amyloid fibril epitope

1 reference

7 January 2021

Protein folding revisited. A polypeptide chain at the folding ? misfolding ? nonfolding cross-roads: which way to go?

1 reference

7 January 2021

A one-hit model of cell death in inherited neuronal degenerations

1 reference

7 January 2021

Principles of protein folding, misfolding and aggregation

1 reference

7 January 2021

Therapeutic strategies for human amyloid diseases

1 reference

7 January 2021

Structural Neurology: Are Seeds at the Root of Neuronal Degeneration?

1 reference

7 January 2021

Unfolding the role of protein misfolding in neurodegenerative diseases

1 reference

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

7 January 2021

The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases

1 reference

7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

7 January 2021

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

1 reference

7 January 2021

α-Synuclein in Lewy bodies

1 reference

7 January 2021

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

1 reference

7 January 2021

SUMO modification of Huntingtin and Huntington's disease pathology

1 reference

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

7 January 2021

Nuclear targeting of mutant Huntingtin increases toxicity

1 reference

7 January 2021

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

1 reference

7 January 2021

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

1 reference

7 January 2021

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

1 reference

7 January 2021

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

1 reference

7 January 2021

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

7 January 2021

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

1 reference

7 January 2021

Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein

1 reference

7 January 2021

Diseases of protein conformation: what do in vitro experiments tell us about in vivo diseases?

1 reference

7 January 2021

Ideas of order for amyloid fibril structure

1 reference

7 January 2021

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-β protein

1 reference

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

7 January 2021

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

1 reference

7 January 2021

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

1 reference

7 January 2021

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

7 January 2021

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

7 January 2021

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

1 reference

7 January 2021

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

1 reference

7 January 2021

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

1 reference

7 January 2021

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

7 January 2021

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

7 January 2021

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

1 reference

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

7 January 2021

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

7 January 2021

Molecular chaperones and the art of recognizing a lost cause

1 reference

7 January 2021

Protein degradation and protection against misfolded or damaged proteins

1 reference

7 January 2021

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

7 January 2021

Aggresomes, inclusion bodies and protein aggregation

1 reference

7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

7 January 2021

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

1 reference

7 January 2021

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

1 reference

7 January 2021

Geldanamycin restores a defective heat shock response in vivo

1 reference

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

7 January 2021

Molecular medicine for the brain: silencing of disease genes with RNA interference

1 reference

7 January 2021

Allele-specific silencing of dominant disease genes

1 reference

7 January 2021

Immunotherapeutic Approaches to Alzheimer's Disease

1 reference

7 January 2021

Good and Bad Amyloid Antibodies

1 reference

7 January 2021

Inflammation and therapeutic vaccination in CNS diseases

1 reference

7 January 2021

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

1 reference

7 January 2021

Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates

1 reference

7 January 2021

Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library

1 reference

7 January 2021

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

1 reference

7 January 2021

Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).

1 reference

7 January 2021

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

1 reference

7 January 2021

A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor

1 reference

7 January 2021

Human β-Secretase (BACE) and BACE Inhibitors

1 reference

7 January 2021

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1066

2 references

27 March 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1046979009

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15272267

1 reference

Consolidated OpenCitations Corpus – April 2017