(Q33799683)

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Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine

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Europe PubMed Central

PubMed publication ID

29 July 2017

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

transmembrane protein

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1 reference

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author name string

Julie R Field

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

L Keith Henry

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Randy D Blakely

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

16 February 2010

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Europe PubMed Central

PubMed publication ID

29 July 2017

number of pages

11

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

29 July 2017

285

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Europe PubMed Central

PubMed publication ID

29 July 2017

15

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

11270-11280

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Unlocking the molecular secrets of sodium-coupled transporters.

1 reference

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4 July 2018

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

1 reference

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4 July 2018

A competitive inhibitor traps LeuT in an open-to-out conformation

1 reference

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4 July 2018

Enhanced activity of human serotonin transporter variants associated with autism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

1 reference

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4 July 2018

Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies

1 reference

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4 July 2018

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

1 reference

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4 July 2018

The binding sites for cocaine and dopamine in the dopamine transporter overlap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Bound to be different: neurotransmitter transporters meet their bacterial cousins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Glycine residues G338 and G342 are important determinants for serotonin transporter dimerisation and cell surface expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Substituted cysteine accessibility of the third transmembrane domain of the creatine transporter: defining a transport pathway

1 reference

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4 July 2018

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Amphetamine induces dopamine efflux through a dopamine transporter channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Regulating the conducting states of a mammalian serotonin transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Flux coupling in the human serotonin transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Accessibility and conformational coupling in serotonin transporter predicted internal domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Oligomerization of serotonin transporter and its functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Characterization of carrier-mediated efflux in human embryonic kidney 293 cells stably expressing the rat serotonin transporter: a superfusion study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Permeation and gating residues in serotonin transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Homologies and family relationships among Na+/Cl- neurotransmitter transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

The Third Transmembrane Domain of the Serotonin Transporter Contains Residues Associated with Substrate and Cocaine Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Simple Allosteric Model for Membrane Pumps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

4 July 2018

Production, purification, and characterization of recombinant 2', 5'-oligoadenylate synthetases

1 reference

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21 January 2018

Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

The cytoplasmic substrate permeation pathway of serotonin transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

The substrates of the gamma-aminobutyric acid transporter GAT-1 induce structural rearrangements around the interface of transmembrane domains 1 and 6.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

Preservation and staining of myelinated nerve fibers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.093658

21 January 2018

Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857005

30 October 2018

The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

12 December 2020

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The yeast mitochondrial citrate transport protein. Probing the secondary structure of transmembrane domain iv and identification of residues that likely comprise a portion of the citrate translocation pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

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1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

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External cysteine residues in the serotonin transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

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inferred from PubMed ID database lookup

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

12 December 2020

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Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

12 December 2020

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Ion-coupled neurotransmitter transport: thermodynamic vs. kinetic determinations of stoichiometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

12 December 2020

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Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

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Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20159976

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inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.093658

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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