(Q28212390)

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Neurosteroids: biochemistry and clinical significance

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Neurosteroids: biochemistry and clinical significance (English)

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Synthia H Mellon

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Lisa D Griffin

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2002

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Trends in Endocrinology and Metabolism

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13

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35-43

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Neurosteroids: biosynthesis and function of these novel neuromodulators

1 reference

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Neurosteroids: a novel function of the brain

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Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1 reference

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7 January 2021

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Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells

1 reference

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7 January 2021

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Cytochrome P450 Side-Chain Cleavage Enzyme in the Cerebellar Purkinje Neuron and Its Neonatal Change in Rats1

1 reference

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7 January 2021

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inferred from DOI database lookup

Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3beta-hydroxysteroid dehydrogenase in the rat brain

1 reference

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7 January 2021

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Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor

1 reference

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7 January 2021

based on heuristic

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Neurosteroid modulation of native and recombinant GABAA receptors.

1 reference

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7 January 2021

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inferred from DOI database lookup

Modulation of the GABA receptor complex by a steroid anaesthetic

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Desensitization and noncompetitive blockade of GABAA receptors in ventral midbrain neurons by a neurosteroid dehydroepiandrosterone sulfate

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Delta subunit inhibits neurosteroid modulation of GABAA receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neurosteroids and GABAA receptor function.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropsychopharmacological properties of neuroactive steroids

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Progesterone synthesis and myelin formation by Schwann cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one induces cytoarchitectural regression in cultured fetal hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Prenatal experience and postnatal stress modulate the adult neurosteroid and catecholaminergic stress responses

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Behaviorally Selective Effects of Neuroactive Steroids on Plus-Maze Anxiety in Mice

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone is an anxiolytic in mice on the plus maze

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Hormones and epilepsy through the lifetime

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Recent Advances in the Endocrinology of Puberty

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Unbalanced progesterone and estradiol secretion in catamenial epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Catamenial epilepsy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Intermittent progesterone therapy and frequency of complex partial seizures in women with menstrual disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

The neurosteroid 3 alpha, 5 apha-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3 alpha,5 alpha-THP.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Sex hormones and alcohol withdrawal: does a good supply of testosterone prevent serious symptoms during detoxification?

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Castration alters susceptibility of male rats to specific seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Behavioral effects of 3 alpha-androstanediol. I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Analgesic effects of the neurosteroid 3 alpha-androstanediol

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via sigma 1-receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Progesterone is neuroprotective after acute experimental spinal cord trauma in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Progesterone metabolite allopregnanolone in women with premenstrual syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Allopregnanolone concentrations and premenstrual syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: a systematic review

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of antidepressant treatment on neuroactive steroids in major depression

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum allopregnanolone levels in pregnant women: changes during pregnancy, at delivery, and in hypertensive patients

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-2760%2801%2900503-3

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/S1043-2760(01)00503-3

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