(Q40709427)

23 September 2017

title

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions (English)

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23 September 2017

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23 September 2017

Yvon Trottier

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Jean-Louis Mandel

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23 September 2017

Bernhard Landwehrmeyer

object named as

G Bernhard Landwehrmeyer

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23 September 2017

Astrid Lunkes

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23 September 2017

Katrin S Lindenberg

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23 September 2017

Léa Ben-Haïem

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23 September 2017

Chantal Weber

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23 September 2017

publication date

1 August 2002

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

259-269

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The MEROPS database as a protease information system

23 September 2017

cites work

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7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

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7 January 2021

A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

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7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brain

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7 January 2021

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

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7 January 2021

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

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7 January 2021

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

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7 January 2021

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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7 January 2021

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

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7 January 2021

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

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7 January 2021

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

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7 January 2021

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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7 January 2021

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

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7 January 2021

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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7 January 2021

A cellular model that recapitulates major pathogenic steps of Huntington's disease

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7 January 2021

Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease.

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7 January 2021

Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.

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7 January 2021

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

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7 January 2021

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

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7 January 2021

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

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7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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7 January 2021

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

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7 January 2021

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

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7 January 2021

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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7 January 2021

Neuropathological classification of Huntington's disease

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7 January 2021

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900602-0

7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

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7 January 2021

Glutamine repeats and neurodegeneration

1 reference

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7 January 2021

10.1016/S1097-2765(02)00602-0

Identifiers

DOI

1 reference

23 September 2017

1 reference