(Q28259003)

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PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics

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PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics (English)

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clinical chemistry

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author name string

Kiran Mahajan

1

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Nupam P Mahajan

2

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September 2012

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Journal of Cellular Physiology

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227

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9

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3178-84

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

1 reference

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20 March 2017

Emerging roles for the non-canonical IKKs in cancer

1 reference

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20 March 2017

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

1 reference

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20 March 2017

Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor

1 reference

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20 March 2017

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

1 reference

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20 March 2017

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation

1 reference

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20 March 2017

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

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20 March 2017

AKT/PKB signaling: navigating downstream

1 reference

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20 March 2017

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation

1 reference

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20 March 2017

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

1 reference

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20 March 2017

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1 reference

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1 reference

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1 reference

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20 March 2017

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1 reference

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20 March 2017

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1 reference

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20 March 2017

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1 reference

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20 March 2017

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1 reference

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20 March 2017

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

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20 March 2017

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

20 March 2017

Diverse somatic mutation patterns and pathway alterations in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

7 April 2017

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

7 April 2017

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

7 April 2017

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

7 April 2017

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

7 April 2017

Selective PI3Kδ inhibitors, a review of the patent literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

1 reference

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29 September 2017

Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma.

1 reference

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Microenvironment and Pathogenesis of Epithelial Ovarian Cancer

1 reference

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29 September 2017

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

1 reference

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1 reference

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29 September 2017

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

1 reference

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1 reference

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29 September 2017

TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

New driver mutations in non-small-cell lung cancer

1 reference

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29 September 2017

IKBKE is over‐expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF‐κB

1 reference

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29 September 2017

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

1 reference

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29 September 2017

Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

1 reference

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29 September 2017

Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

1 reference

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29 September 2017

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

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29 September 2017

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1 reference

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29 September 2017

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

1 reference

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29 September 2017

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1 reference

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29 September 2017

A new mutational AKTivation in the PI3K pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Dynamic FoxO transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

All roads lead to IKKepsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.

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1 reference

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29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

V(D)J recombination: RAG proteins, repair factors, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

29 September 2017

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1 reference

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2 June 2018

Somatic mutations are present in all members of the AKT family in endometrial carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

2 June 2018

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1 reference

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2 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

2 June 2018

PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

2 June 2018

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

2 June 2018

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

27 November 2018

Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

27 November 2018

The Akt pathway in human breast cancer: a tissue-array-based analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

27 November 2018

The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3358464

27 November 2018

Anticancer drugs: a Notch closer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22307544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3 kinases in cancer: from oncogene artifact to leading cancer target

1 reference

https://pubmed.ncbi.nlm.nih.gov/22307544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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