(Q34592027)

3 August 2017

title

Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations (English)

1 reference

3 August 2017

B Vogelstein

1 reference

3 August 2017

M Reis

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H Konishi

0 references

J Lauring

1 reference

3 August 2017

D P Cosgrove

1 reference

3 August 2017

S Fontana

1 reference

3 August 2017

J P Gustin

1 reference

3 August 2017

A M Abukhdeir

1 reference

3 August 2017

J P Garay

1 reference

3 August 2017

M Mohseni

1 reference

3 August 2017

G M Wang

1 reference

3 August 2017

M J Higgins

1 reference

3 August 2017

D Gorkin

1 reference

3 August 2017

K Polyak

1 reference

3 August 2017

M Cowherd

1 reference

3 August 2017

P J Buckhaults

1 reference

3 August 2017

B H Park

1 reference

3 August 2017

language of work or name

English

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publication date

25 January 2010

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3 August 2017

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

2337-2345

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Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

3 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Knockin of mutant PIK3CA activates multiple oncogenic pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

A novel AKT3 mutation in melanoma tumours and cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

The consensus coding sequences of human breast and colorectal cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

AKT1(E17K) in human solid tumours

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.516

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.516

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.516

Biochemical and biological characterization of tumor-associated mutations of p110alpha.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

The PIK3CA gene is mutated with high frequency in human breast cancers.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042798

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma

27 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.516

PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.516

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.516

1 reference

Dimensions Publication ID

3 August 2017

0 references

1 reference

3 August 2017

1 reference